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Fgf7 and Fgf10, the main ligands for FgfR2-IIIb, are expressed in the mesenchyme surrounding the thymic epithelial primordium, and Fgf10-deficient mice also exhibit impaired thymic growth. Hence, Fgf signaling is essential for thymic epithelial proliferation. In addition to the proliferative block, most thymic epithelial cells fail to progress from an immature cytokeratin 5-positive to a cytokeratin 5-negative phenotype. Nevertheless, sufficient epithelial cell differentiation occurs in the severely hypoplastic thymus to allow the development of CD4\/CD8-double-positive thymocytes and a very small number of single-positive thymocytes expressing TCRs.<\/jats:p>","DOI":"10.4049\/jimmunol.167.4.1954","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T19:18:03Z","timestamp":1398194283000},"page":"1954-1961","source":"Crossref","is-referenced-by-count":207,"title":["Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb"],"prefix":"10.1093","volume":"167","author":[{"given":"Jean-Michel","family":"Revest","sequence":"first","affiliation":[{"name":"Imperial Cancer Research Fund , London ,","place":["U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder K","family":"Suniara","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Medical School, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kerr","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund , London ,","place":["U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J T","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Medical School, University of Birmingham , Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Dickson","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund , London ,","place":["U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,8,15]]},"reference":[{"key":"2026020209090325600_R1","first-page":"227","volume-title":"Am. 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