{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:12:53Z","timestamp":1791159173457,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have analyzed the blood B cell subpopulations of children with systemic lupus erythematosus (SLE) and healthy controls. We found that the normal recirculating mature B cell pool is composed of four subsets: conventional naive and memory B cells, a novel B cell subset with pregerminal center phenotype (IgD+CD38+centerin+), and a plasma cell precursor subset (CD20\u2212CD19+\/lowCD27+\/++ CD38++). In SLE patients, naive and memory B cells (CD20+CD38\u2212) are \u223c90% reduced, whereas oligoclonal plasma cell precursors are 3-fold expanded, independently of disease activity and modality of therapy. Pregerminal center cells in SLE are decreased to a lesser extent than conventional B cells, and therefore represent the predominant blood B cell subset in a number of patients. Thus, SLE is associated with major blood B cell subset alterations.<\/jats:p>","DOI":"10.4049\/jimmunol.167.4.2361","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T19:18:03Z","timestamp":1398194283000},"page":"2361-2369","source":"Crossref","is-referenced-by-count":217,"title":["Increased Frequency of Pre-germinal Center B Cells and Plasma Cell Precursors in the Blood of Children with Systemic Lupus Erythematosus"],"prefix":"10.1093","volume":"167","author":[{"given":"Edsel","family":"Arce","sequence":"first","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah G","family":"Jackson","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A","family":"Gill","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda B","family":"Bennett","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Banchereau","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Pascual","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,8,15]]},"reference":[{"key":"2026020209114379400_R1","first-page":"42","volume-title":"Arthritis Rheum.","year":"1999"},{"key":"2026020209114379400_R2","first-page":"S235","volume-title":"Arthritis Rheum.","year":"2000"},{"key":"2026020209114379400_R3","first-page":"295","volume-title":"Arthritis Rheum.","year":"1978"},{"key":"2026020209114379400_R4","first-page":"157","volume-title":"Immunol. Rev.","year":"1995"},{"key":"2026020209114379400_R5","first-page":"107","volume-title":"Immunol. Rev.","year":"1999"},{"key":"2026020209114379400_R6","first-page":"454","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020209114379400_R7","first-page":"1295","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2026020209114379400_R8","first-page":"75","volume-title":"Ann. NY Acad. Sci.","year":"1997"},{"key":"2026020209114379400_R9","first-page":"853","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020209114379400_R10","first-page":"345","volume-title":"Am. J. Med.","year":"1980"},{"key":"2026020209114379400_R11","first-page":"3988","volume-title":"J. Immunol.","year":"1989"},{"key":"2026020209114379400_R12","first-page":"2549","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2026020209114379400_R13","first-page":"199","volume-title":"Clin. Immunol. Immunopathol.","year":"1997"},{"key":"2026020209114379400_R14","first-page":"2063","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2026020209114379400_R15","first-page":"1639","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020209114379400_R16","first-page":"871","volume-title":"Arthritis Rheum.","year":"1999"},{"key":"2026020209114379400_R17","first-page":"947","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2026020209114379400_R18","first-page":"169","volume-title":"Semin. Immunol.","year":"1996"},{"key":"2026020209114379400_R19","first-page":"111","volume-title":"Immunol. Rev.","year":"1997"},{"key":"2026020209114379400_R20","first-page":"603","volume-title":"Immunity","year":"1996"},{"key":"2026020209114379400_R21","first-page":"204","volume-title":"Immunol. Today","year":"2000"},{"key":"2026020209114379400_R22","first-page":"1679","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020209114379400_R23","first-page":"1107","volume-title":"Eur. J. Immunol.","year":"1991"},{"key":"2026020209114379400_R24","first-page":"3345","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020209114379400_R25","first-page":"241","volume-title":"Immunity","year":"1996"},{"key":"2026020209114379400_R26","first-page":"931","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020209114379400_R27","first-page":"1165","volume-title":"J. Exp. Med.","year":"1991"},{"key":"2026020209114379400_R28","first-page":"1293","volume-title":"J. Exp. Med.","year":"1993"},{"key":"2026020209114379400_R29","first-page":"1635","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020209114379400_R30","first-page":"751","volume-title":"Nature","year":"1996"},{"key":"2026020209114379400_R31","first-page":"530","volume-title":"Arthritis Rheum.","year":"1984"},{"key":"2026020209114379400_R32","first-page":"1354","volume-title":"Arthritis Rheum.","year":"1999"},{"key":"2026020209114379400_R33","first-page":"329","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2026020209114379400_R34","first-page":"59","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020209114379400_R35","first-page":"219","volume-title":"Nucleic Acids Res.","year":"2000"},{"key":"2026020209114379400_R36","first-page":"111","volume-title":"Am. J. Clin. Pathol.","year":"1993"},{"key":"2026020209114379400_R37","first-page":"388","volume-title":"J. Pediatr.","year":"1997"},{"key":"2026020209114379400_R38","first-page":"3039","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2026020209114379400_R39","first-page":"563","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020209114379400_R40","first-page":"184","volume-title":"Br. J. Hematol.","year":"1996"},{"key":"2026020209114379400_R41","first-page":"701","volume-title":"Blood","year":"1999"},{"key":"2026020209114379400_R42","first-page":"2437","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2026020209114379400_R43","first-page":"5970","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020209114379400_R44","first-page":"217","volume-title":"Clin. Exp. Immunol.","year":"1969"},{"key":"2026020209114379400_R45","first-page":"21","volume-title":"Clin. Rheumatol.","year":"1994"},{"key":"2026020209114379400_R46","first-page":"54","volume-title":"Cell. Immunol.","year":"1999"},{"key":"2026020209114379400_R47","first-page":"650","volume-title":"Am. J. Clin. Pathol.","year":"1989"},{"key":"2026020209114379400_R48","first-page":"387","volume-title":"Ann. Intern. Med.","year":"1991"},{"key":"2026020209114379400_R49","first-page":"1303","volume-title":"J. Rheumatol.","year":"1992"},{"key":"2026020209114379400_R50","first-page":"77","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020209114379400_R51","first-page":"562","volume-title":"Clin. Exp. Immunol.","year":"1987"},{"key":"2026020209114379400_R52","first-page":"2140","volume-title":"J. Exp. Med.","year":"1983"},{"key":"2026020209114379400_R53","first-page":"914","volume-title":"Arthritis Rheum.","year":"1989"},{"key":"2026020209114379400_R54","first-page":"1431","volume-title":"Arthritis Rheum.","year":"2000"},{"key":"2026020209114379400_R55","first-page":"79","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020209114379400_R56","first-page":"1243","volume-title":"Int. Immunol.","year":"1995"},{"key":"2026020209114379400_R57","first-page":"2273","volume-title":"J. Rheumatol.","year":"1997"},{"key":"2026020209114379400_R58","first-page":"839","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020209114379400_R59","first-page":"1790","volume-title":"Arthritis Rheum.","year":"2000"},{"key":"2026020209114379400_R60","first-page":"785","volume-title":"Curr. Biol.","year":"2000"},{"key":"2026020209114379400_R61","first-page":"3370","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020209114379400_R62","first-page":"260","volume-title":"Science","year":"1999"},{"key":"2026020209114379400_R63","first-page":"995","volume-title":"Nature","year":"2000"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/167\/4\/2361\/62545553\/2361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/167\/4\/2361\/62545553\/2361.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:15:41Z","timestamp":1770041741000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/167\/4\/2361\/8025554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,8,15]]},"published-print":{"date-parts":[[2001,8,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.167.4.2361","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,8]]},"published":{"date-parts":[[2001,8]]}}}