{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T14:59:57Z","timestamp":1773673197332,"version":"3.50.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although evidence indicates that environmental factors play a major role in precipitating systemic autoimmunity in genetically susceptible individuals, little is known about the mechanisms involved. Certain heavy metals, such as mercury, are potent environmental immunostimulants that produce a number of immunopathologic sequelae, including lymphoproliferation, hypergammaglobulinemia, and overt systemic autoimmunity. Predisposition to such metal-induced immunopathology has been shown to be influenced by both MHC and non-MHC genes, as well as susceptibility to spontaneous lupus, in mice and other experimental animals. Among the various mouse strains examined to date, the DBA\/2 appears to uniquely lack susceptibility to mercury-induced autoimmunity (HgIA), despite expressing a susceptible H-2 haplotype (H-2d). To define the genetic basis for this trait, two genome-wide scans were conducted using F2 intercrosses of the DBA\/2 strain with either the SJL or NZB strains, both of which are highly susceptible to HgIA. A single major quantitative trait locus on chromosome 1, designated Hmr1, was shown to be common to both crosses and encompassed a region containing several lupus susceptibility loci. Hmr1 was linked to glomerular immune complex deposits and not autoantibody production, suggesting that DBA\/2 resistance to HgIA may primarily involve the later stages of disease pathogenesis. Identification and characterization of susceptibility\/resistance genes and mechanisms relevant to the immunopathogenesis of mercury-induced autoimmunity should provide important insights into the pathogenesis of autoimmunity and may reveal novel targets for intervention.<\/jats:p>","DOI":"10.4049\/jimmunol.167.4.2396","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T19:18:03Z","timestamp":1398194283000},"page":"2396-2403","source":"Crossref","is-referenced-by-count":41,"title":["Resistance to Xenobiotic-Induced Autoimmunity Maps to Chromosome 1"],"prefix":"10.1093","volume":"167","author":[{"given":"Dwight H","family":"Kono","sequence":"first","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyo S","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Szydlik","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina M","family":"Haraldsson","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah L","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Experimental Medicine, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Hultman","sequence":"additional","affiliation":[{"name":"Division of Molecular and Immunological Pathology, Department of Health and Environment, Linko\u0308ping University , Linko\u0308ping ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K Michael","family":"Pollard","sequence":"additional","affiliation":[{"name":"Department of Molecular and Experimental Medicine, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,8,15]]},"reference":[{"key":"2026020209093139900_R1","first-page":"399","volume-title":"Semin. 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