{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:22:51Z","timestamp":1770085371287,"version":"3.49.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pertussis (P) toxin acts as adjuvant for IgE formation against simultaneously administered Ags in animal models. P vaccination may also have an adjuvant impact on IgE formation against coadministered diphtheria (D) and tetanus (T) Ags in humans. Sera of 103 D-T-P-immunized and 319 D-T-immunized children aged 2 years were analyzed for IgE, IgG4, and IgG to D and T (radioallergosorbent test), total IgE and IgE against common inhalant allergens (CAP radioallergosorbent test fluoroenzyme immunoassay). Fewer D-T-P- than D-T-immunized children had sera positive for T-IgE (12.6 vs 53.6%, p &amp;lt; 0.001), T-IgG4 (71.6 vs 89.2%, p &amp;lt; 0.001), D-IgE (31.0 vs 70.5%, p &amp;lt; 0.001), and D-IgG4 (85.2 vs 93.4%, p = 0.039). Suppression of T-IgE was not dependent on the cutoff chosen for a positive test result, but was dependent on the proportion of D-T immunizations given with P. The risk for sensitization to common environmental allergens did not differ (odds ratio 0.953, 95% confidence interval 0.815\u20131.114). No significant differences between D-T- and D-T-P-immunized children were found with regard to T-IgG or D-IgG. In summary, IgE and IgG4 (but not IgG) serum levels to coadministered D- and T-Ags are suppressed among P-immunized children as compared with nonimmunized children. These results suggest that the presence of a microbial product during Ag exposure can down-regulate an IgE\/IgG4 response in humans.<\/jats:p>","DOI":"10.4049\/jimmunol.167.4.2411","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T19:18:03Z","timestamp":1398194283000},"page":"2411-2417","source":"Crossref","is-referenced-by-count":25,"title":["Down-Regulation of IgE and IgG4 Antibodies to Tetanus Toxoid and Diphtheria Toxoid by Covaccination with Cellular\n                    <i>Bordetella pertussis<\/i>\n                    Vaccine"],"prefix":"10.1093","volume":"167","author":[{"given":"Christoph","family":"Gru\u0308ber","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, Charite\u0301-Humboldt University , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, Charite\u0301-Humboldt University , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almut","family":"Dannemann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, Charite\u0301-Humboldt University , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Sommerfeld","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, Charite\u0301-Humboldt University , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Wahn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, Charite\u0301-Humboldt University , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob C","family":"Aalberse","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,8,15]]},"reference":[{"key":"2026020209094889500_R1","first-page":"45","volume-title":"Clin. 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