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Under certain circumstances (e.g., in neonatals or AIDS patients), the infection becomes disseminated, often with severe consequences. Spread of HSV-1 is limited by virus-specific Ab. The development of an efficient humoral response to the virus is dependent on innate immunity component complement C3. The liver is the major source of C3, but there are also extrahepatic origins of C3 such as lymphoid macrophages. In the present study, the significance of C3 synthesis by bone marrow-derived cells was assessed by the transfer of wild-type bone marrow into irradiated C3-deficient mice. Using these chimeric mice, extrahepatic C3 was determined sufficient to initiate specific Ab and memory responses to a peripheral HSV-1 infection.<\/jats:p>","DOI":"10.4049\/jimmunol.167.5.2446","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:43:49Z","timestamp":1398023029000},"page":"2446-2451","source":"Crossref","is-referenced-by-count":56,"title":["Cutting Edge: Myeloid Complement C3 Enhances the Humoral Response To Peripheral Viral Infection"],"prefix":"10.1093","volume":"167","author":[{"given":"Admar","family":"Verschoor","sequence":"first","affiliation":[{"name":"Pathology, Harvard Medical School , Boston, MA 02115"},{"name":"The Center for Blood Research , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Brockman","sequence":"additional","affiliation":[{"name":"Microbiology and Molecular Genetics, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Knipe","sequence":"additional","affiliation":[{"name":"Microbiology and Molecular Genetics, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C","family":"Carroll","sequence":"additional","affiliation":[{"name":"Pediatrics, Harvard Medical School , Boston, MA 02115"},{"name":"The Center for Blood Research , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"2026020208045832300_R1","volume-title":"The Human Herpes Viruses: Biology, Pathogenesis, and Treatment","year":"1993"},{"key":"2026020208045832300_R2","first-page":"619","volume-title":"Ann. 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