{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:25:42Z","timestamp":1790234742969,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD84 is a member of the CD2 subset of the Ig superfamily of cell surface molecules. Its cytoplasmic tail binds to Src homology 2 domain-containing protein 1A (signaling lymphocytic activation molecule-associated protein), a protein encoded by the X-linked lymphoproliferative disease gene. It is preferentially expressed on B lymphocytes, monocytes, and platelets. We show that it is also expressed on thymocytes and T cells. CD84 was positive on CD4\u2212CD8\u2212 thymocytes, and its expression decreased with cell maturation. It is expressed on mature T cells preferentially on CD45RO+. To identify the CD84 ligand, we generated a soluble Ig fusion protein containing the human CD84 extracellular domains (CD84-Ig). Because receptor-ligand interactions occur between several members of this subfamily, we assayed CD84-Ig binding with all members of the CD2 family. CD84-Ig bound to CD84-transfected cells, whereas no binding was detected with cells expressing other CD2 subfamily receptors, showing that CD84 binds to itself. Anti-CD84 mAbs recognizing epitopes wholly within domain 1 of CD84 blocked the binding of the CD84-Ig fusion protein to CD84-transfected cells and platelets. Data from CD84 domain human\/mouse chimeras further revealed that only the first extracellular domain of the molecule is involved in the ligand receptor recognition. The CD84-CD84 interaction was independent of its cytoplasmic tail. Finally, concurrent ligation of human CD84 with mAbs or CD84-Ig and CD3 enhanced IFN-\u03b3 secretion in human lymphocytes. Thus, CD84 is its own ligand and acts as a costimulatory molecule.<\/jats:p>","DOI":"10.4049\/jimmunol.167.7.3668","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:21:00Z","timestamp":1398122460000},"page":"3668-3676","source":"Crossref","is-referenced-by-count":113,"title":["CD84 Functions as a Homophilic Adhesion Molecule and Enhances IFN-\u03b3 Secretion: Adhesion Is Mediated by Ig-Like Domain 1"],"prefix":"10.1093","volume":"167","author":[{"given":"Margarita","family":"Martin","sequence":"first","affiliation":[{"name":"Immunology Unit, Department of Cellular Biology and Pathology, Medical School, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Romero","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Cellular Biology and Pathology, Medical School, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Cellular Biology and Pathology, Medical School, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Tovar","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Cellular Biology and Pathology, Medical School, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nu\u0301ria","family":"Zapater","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Cellular Biology and Pathology, Medical School, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Esplugues","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Biology, University of Barcelona, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Pizcueta","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Engel","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Cellular Biology and Pathology, Medical School, Hospital Clinic, Institut d\u2019Investigacions Biome\u0300diques August Pi ySunyer , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,10,1]]},"reference":[{"key":"2026020208140585200_R1","first-page":"149","volume-title":"Semin. 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