{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:32:42Z","timestamp":1790015562478,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Current therapeutic approaches to asthma have had limited impact on the clinical management and resolution of this disorder. By using a novel vaccine strategy targeting the inflammatory cytokine IL-5, we have ameliorated hallmark features of asthma in mouse models. Delivery of a DNA vaccine encoding murine IL-5 modified to contain a promiscuous foreign Th epitope bypasses B cell tolerance to IL-5 and induces neutralizing polyclonal anti-IL-5 Abs. Active vaccination against IL-5 reduces airways inflammation and prevents the development of eosinophilia, both hallmark features of asthma in animal models and humans. The reduced numbers of inflammatory T cells and eosinophils in the lung also result in a marked reduction of Th2 cytokine levels. Th-modified IL-5 DNA vaccination reduces the expression of IL-5 and IL-4 by \u223c50% in the airways of allergen-challenged mice. Most importantly, Th-modified IL-5 DNA vaccination restores normal bronchial hyperresponsiveness to \u03b2-methacholine. Active vaccination against IL-5 reduces key pathological events associated with asthma, such as Th2 cytokine production, airways inflammation, and hyperresponsiveness, and thus represents a novel therapeutic approach for the treatment of asthma and other allergic conditions.<\/jats:p>","DOI":"10.4049\/jimmunol.167.7.3792","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:21:00Z","timestamp":1398122460000},"page":"3792-3799","source":"Crossref","is-referenced-by-count":62,"title":["Active Vaccination Against IL-5 Bypasses Immunological Tolerance and Ameliorates Experimental Asthma"],"prefix":"10.1093","volume":"167","author":[{"given":"Marc","family":"Hertz","sequence":"first","affiliation":[{"name":"Pharmexa A\/S , H\u00f8rsholm ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendran","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iben","family":"Dalum","sequence":"additional","affiliation":[{"name":"Pharmexa A\/S , H\u00f8rsholm ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Klysner","sequence":"additional","affiliation":[{"name":"Pharmexa A\/S , H\u00f8rsholm ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Mattes","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Neisig","sequence":"additional","affiliation":[{"name":"Pharmexa A\/S , H\u00f8rsholm ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Mouritsen","sequence":"additional","affiliation":[{"name":"Pharmexa A\/S , H\u00f8rsholm ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S","family":"Foster","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Gautam","sequence":"additional","affiliation":[{"name":"Pharmexa A\/S , H\u00f8rsholm ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,10,1]]},"reference":[{"key":"2026020208144172300_R1","first-page":"373","volume-title":"Am. 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