{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:40:59Z","timestamp":1791042059459,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Murine models of lymphocytic choriomeningitis virus infection suggest that the memory CD8+ T cell repertoire is reflective of the CD8+ T cell repertoire generated during acute infection. Less is known regarding the evolution of CD8+ T cell repertoires during human viral infections. We therefore examined epitope-specific CD8+ T cell responses in a large cohort of individuals with acute through latent Epstein-Barr virus infection. Using 16 of 20 published EBV epitopes restricted by HLA-A2, HLA-A3 or HLA-B7, we showed that lytic cycle-specific CD8+ T cell responses predominated during acute EBV infection. However, whereas HLA-A2+-restricted BMLF-1-specific CD8+ T cell responses were maintained through latency, HLA-A2+- and HLA-B7+-restricted BZLF-1, as well as HLA-A3+-restricted BRLF-1 CD8+ T cell responses, were generated but not readily maintained. Analyses of CD8+ T cell responses to EBV latent cycle Ags showed delayed detection and lower frequencies of latent epitope-specific CD8+ T cell responses during acute EBV infection, with maintenance of these responses 1 yr post-EBV infection. Early BMLF-1 and EBNA-3A epitope-specific CD8+ T cell frequencies did not correlate with their frequencies at 1 yr postinfection. Interestingly, populations of EBV-specific CD8+ T cells were stable during 20 mo in our long term EBV-seropositive populations, suggesting homeostasis between virus and the host immune system. This study demonstrates that CD8+ T cell repertoires generated during persistent viral infections are not simply reflective of the initial pool of CD8+ T cells and provides evidence that the generation of CD8+ T cell responses to a persistent infection is a dynamic process.<\/jats:p>","DOI":"10.4049\/jimmunol.167.8.4450","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:47:50Z","timestamp":1398023270000},"page":"4450-4457","source":"Crossref","is-referenced-by-count":83,"title":["Differential Evolution and Stability of Epitope-Specific CD8+ T Cell Responses in EBV Infection"],"prefix":"10.1093","volume":"167","author":[{"given":"Michelle D","family":"Catalina","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Luzuriaga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,10,15]]},"reference":[{"key":"2026020208052215200_R1","first-page":"1225","volume-title":"N. 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