{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:21:49Z","timestamp":1791116509567,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Viral infections are often accompanied by extensive proliferation of reactive CD8 T cells. After a defined number of divisions, normal somatic cells enter a nonreplicative stage termed senescence. In the present study we have identified the inhibitory killer cell lectin-like receptor G1 (KLRG1) as a unique marker for replicative senescence of murine CD8 T cells. KLRG1 expression was induced in a substantial portion (30\u201360%) of CD8 T cells in C57BL\/6 mice infected with lymphocytic choriomeningitis virus (LCMV), vesicular stomatitis virus, or vaccinia virus. Similarly, KLRG1 was found on a large fraction of LCMV gp33 peptide-specific TCR-transgenic (tg) effector and memory cells activated in vivo using an adoptive transfer model. Transfer experiments with CFSE-labeled TCR-tg cells into LCMV-infected hosts further indicated that induction of KLRG1 expression required an extensive number of cell divisions. Most importantly, KLRG1+ TCR-tg effector\/memory cells could efficiently lyse target cells and secrete cytokines, but were severely impaired in their ability to proliferate after Ag stimulation. Thus, this study demonstrates that senescent CD8 T cells are induced in abundant numbers during viral infections in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.167.9.4838","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:19:57Z","timestamp":1398035997000},"page":"4838-4843","source":"Crossref","is-referenced-by-count":195,"title":["Viral Infections Induce Abundant Numbers of Senescent CD8 T Cells"],"prefix":"10.1093","volume":"167","author":[{"given":"David","family":"Voehringer","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Blaser","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Brawand","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne , Epalinges ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Raulet","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California , Berkeley, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hanke","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology, University of Wu\u0308rzburg , Wu\u0308rzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"2026020208062545400_R1","first-page":"84","volume-title":"Science","year":"2000"},{"key":"2026020208062545400_R2","first-page":"228","volume-title":"Immunol. 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