{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:32:48Z","timestamp":1789587168635,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>One of the consequences of HIV infection is damage to the CNS. To characterize the virologic, immunologic, and functional factors involved in HIV-induced CNS disease, we analyzed the viral loads and T cell infiltrates in the brains of SIV-infected rhesus monkeys whose CNS function (sensory evoked potential) was impaired. Following infection, CNS evoked potentials were abnormal, indicating early CNS disease. Upon autopsy at 11 wk post-SIV inoculation, the brains of infected animals contained over 5-fold more CD8+ T cells than did uninfected controls. In both infected and uninfected groups, these CD8+ T cells presented distinct levels of activation markers (CD11a and CD95) at different sites: brain &amp;gt; CSF &amp;gt; spleen = blood &amp;gt; lymph nodes. The CD8+ cells obtained from the brains of infected monkeys expressed mRNA for cytolytic and proinflammatory molecules, such as granzymes A and B, perforin, and IFN-\u03b3. Therefore, the neurological dysfunctions correlated with increased numbers of CD8+ T cells of an activated phenotype in the brain, suggesting that virus-host interactions contributed to the related CNS functional defects.<\/jats:p>","DOI":"10.4049\/jimmunol.167.9.5429","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:19:57Z","timestamp":1398035997000},"page":"5429-5438","source":"Crossref","is-referenced-by-count":91,"title":["Highly Activated CD8+ T Cells in the Brain Correlate with Early Central Nervous System Dysfunction in Simian Immunodeficiency Virus Infection"],"prefix":"10.1093","volume":"167","author":[{"given":"Maria Cecilia Garibaldi","family":"Marcondes","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M E","family":"Burudi","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Huitron-Resendiz","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Sanchez-Alavez","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Watry","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Zandonatti","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard S","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"2026020208040504200_R1","first-page":"557","volume-title":"Annu. 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