{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:51:56Z","timestamp":1791229916145,"version":"4.1.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD8\u03b1+ and CD8\u03b1\u2212 dendritic cells (DCs) arise from committed bone marrow progenitors and can induce or regulate immune reactivity. Previously, the maturational status of CD8\u03b1\u2212 (myeloid) DCs has been shown to influence allogeneic T cell responses and allograft survival. Although CD8\u03b1+ DCs have been implicated in central tolerance and found to modulate peripheral T cell function, their influence on the outcome of organ transplantation has not been examined. Consistent with their equivalent high surface expression of MHC and costimulatory molecules, sorted mature C57BL\/10J (B10; H2b) DCs of either subset primed naive, allogeneic C3H\/HeJ (C3H; H2k) recipients for Th1 responses. Paradoxically and in contrast to their CD8\u03b1\u2212 counterparts, mature CD8\u03b1+ B10 DCs given systemically 7 days before transplant markedly prolonged B10 heart graft survival in C3H recipients. This effect was associated with specific impairment of ex vivo antidonor T cell proliferative responses, which was not reversed by exogenous IL-2. Further analyses of possible underlying mechanisms indicated that neither immune deviation nor induction of regulatory cells was a significant contributory factor. In contrast to the differential capacity of the mature DC subsets to affect graft outcome, immature CD8\u03b1+ and CD8\u03b1\u2212 DCs administered under the same experimental conditions significantly prolonged transplant survival. These observations demonstrate for the first time the innate capacity of CD8\u03b1+ DCs to regulate alloimmune reactivity and transplant survival, independent of their maturation status. Mobilization of such a donor DC subset with capacity to modulate antidonor immunity may have significant implications for the therapy of allograft rejection.<\/jats:p>","DOI":"10.4049\/jimmunol.168.1.143","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:25:14Z","timestamp":1398032714000},"page":"143-154","source":"Crossref","is-referenced-by-count":88,"title":["Immature and Mature CD8\u03b1+ Dendritic Cells Prolong the Survival of Vascularized Heart Allografts"],"prefix":"10.1093","volume":"168","author":[{"given":"Peta J","family":"O\u2019Connell","sequence":"first","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"},{"name":"Department Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"},{"name":"Department Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"},{"name":"Department Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Specht","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"},{"name":"Department Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J","family":"Logar","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"},{"name":"Department Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus W","family":"Thomson","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"},{"name":"Department Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"},{"name":"Department Molecular Genetics and Biochemistry, University of Pittsburgh Medical Center , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"2026020208152737400_R1","first-page":"271","volume-title":"Annu. Rev. Immunol.","year":"1991"},{"key":"2026020208152737400_R2","first-page":"47","volume-title":"Annu. Rev. Immunol.","year":"2001"},{"key":"2026020208152737400_R3","first-page":"41","volume-title":"Trends Immunol.","year":"2001"},{"key":"2026020208152737400_R4","first-page":"357","volume-title":"Immunity","year":"2001"},{"key":"2026020208152737400_R5","first-page":"448","volume-title":"Immunol. 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