{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:49:23Z","timestamp":1789620563655,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Uterine NK (uNK) cells are abundant in human and murine uteri during decidualization. It is unclear whether precursors of uNK (pre-uNK) cells self-renew or are recruited from other sites. To assess self-renewal of pre-uNK cells, uterine segments from NK cell-competent mice were grafted orthotopically into NK\/uNK cell-deficient or wild-type mice. Only in wild-type recipients did decidualized grafts contain uNK cells, indicating that pre-uNK cells do not self-renew in uterus. To identify pre-uNK cell sources, thymus, bone marrow, lymph node, or spleen cells were grafted from virgin or pregnant NK cell-competent donors into mated NK\/uNK cell-deficient recipients. Cells from secondary lymphoid tissues of pregnant donors gave high level uNK cell reconstitution, which was independent of chemokine receptors CCR2 or CCR5. Pregnancy-induced changes to lymphocyte-endothelial cell interactions were documented using adhesion of human lymphocytes to frozen mouse tissue sections under shear. A dynamic increase was observed in L-selectin- and \u03b14 integrin-dependent adhesion of CD56bright NK cells to decidualizing uterus and in human PBL adhesion to lymph node endothelium. These data support a model that attributes the dramatic increases in human and murine uNK cells during decidualization to precursor cell recruitment.<\/jats:p>","DOI":"10.4049\/jimmunol.168.1.22","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:25:14Z","timestamp":1398032714000},"page":"22-28","source":"Crossref","is-referenced-by-count":131,"title":["Contributions from Self-Renewal and Trafficking to the Uterine NK Cell Population of Early Pregnancy"],"prefix":"10.1093","volume":"168","author":[{"given":"Sirirak","family":"Chantakru","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Miller","sequence":"additional","affiliation":[{"name":"Department Clinical Studies, Ontario Veterinary College, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay E","family":"Roach","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A","family":"Kuziel","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Molecular Biology, University of Texas , Austin, TX 78712"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Roswell Park Cancer Institute , Buffalo, NY 14263"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon S","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Immunology, Roswell Park Cancer Institute , Buffalo, NY 14263"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Anne","family":"Croy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"2026020208155741600_R1","first-page":"15","volume-title":"Adv. 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