{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:21:28Z","timestamp":1792178488691,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The role of JC virus (JCV)-specific CTL was explored in the immunopathogenesis of progressive multifocal leukoencephalopathy (PML). We identified a 9-aa epitope of the JCV capsid protein VP1, the VP1p100 peptide ILMWEAVTL, which is recognized by CTL of HLA-A2+ HIV+\/PML survivors. We then constructed an HLA-A*0201\/VP1p100 tetrameric complex that allowed us to assess by flow cytometry the PBMC of 13 PML patients and 11 control subjects for the presence of JCV-specific CTL. VP1p100-specific CTL were detected by tetramer binding in VP1p100-stimulated PBMC of five of seven (71%) PML survivors and zero of six PML progressors (p = 0.02). Two of three HIV+ patients with a leukoencephalopathy resembling PML, but with no virologic evidence of JCV infection, also had detectable VP1p100-specific CTL in their PBMC. PBMC of eight HIV+ patients with other neurologic diseases and healthy control subjects had no detectable JCV-specific CTL. These data suggest that the JCV-specific cellular immune response may be important in the containment of PML, and the tetramer-staining assay may provide a useful prognostic tool in the clinical management of these patients.<\/jats:p>","DOI":"10.4049\/jimmunol.168.1.499","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:25:14Z","timestamp":1398032714000},"page":"499-504","source":"Crossref","is-referenced-by-count":115,"title":["Association of Prolonged Survival in HLA-A2+ Progressive Multifocal Leukoencephalopathy Patients with a CTL Response Specific for a Commonly Recognized JC Virus Epitope"],"prefix":"10.1093","volume":"168","author":[{"given":"Igor J","family":"Koralnik","sequence":"first","affiliation":[{"name":"Neurology Department, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"},{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud A","family":"Du Pasquier","sequence":"additional","affiliation":[{"name":"Neurology Department, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"},{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo J","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rn E","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dang","sequence":"additional","affiliation":[{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lifton","sequence":"additional","affiliation":[{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman L","family":"Letvin","sequence":"additional","affiliation":[{"name":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"2026020208164141200_R1","first-page":"6103","volume-title":"J. 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