{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:59:41Z","timestamp":1770087581316,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The hypothesis that T cell competition for access to APC influences priming of CTL responses is a controversial issue. A recent study using OVA as a model Ag supports this hypothesis and received considerable attention. However, using a comparable approach, we reached a different conclusion. We analyzed whether TCR transgenic T cells specific for lymphocytic choriomeningitis virus gp33\u201341\/Db could inhibit the priming of endogenous responses against gp33\u201341 and against two other lymphocytic choriomeningitis virus glycoprotein-derived CTL epitopes. After priming with different stimuli, gp33\u201341\/Db-specific TCR transgenic T cells reduced the endogenous gp33\u201341\/Db response in a dose-dependent way, but all other endogenous responses were unaffected. Even when &amp;gt;106 TCR transgenic cells were combined with weak priming, no reduction of responses other than of those specific for gp33\u201341\/Db was observed. Thus, competition for APC by CTLs of different specificities is not of functional relevance in antiviral immune responses.<\/jats:p>","DOI":"10.4049\/jimmunol.168.11.5387","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:43:29Z","timestamp":1398120209000},"page":"5387-5391","source":"Crossref","is-referenced-by-count":33,"title":["Cutting Edge: Competition for APC by CTLs of Different Specificities Is Not Functionally Important During Induction of Antiviral Responses"],"prefix":"10.1093","volume":"168","author":[{"given":"Hans Christian","family":"Probst","sequence":"first","affiliation":[{"name":"Institute of Experimental Immunology , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman","family":"Dumrese","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maries F","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology , Zu\u0308rich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"key":"2026020209035878200_R1","first-page":"52","volume-title":"Adv. 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