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Infection with lower doses of both pathogens resulted in stronger bacterial growth but weaker T cell memory indicating that memory correlates with pathogen dose but not with bacterial expansion. The CD8+ T cell response induced by LM-OVA was helper T cell-independent and was characterized by a rapid effector response followed by a rapid, but massive, attrition. In contrast, BCG-OVA induced a delayed and weak response that was compensated for by a longer effector phase and reduced attrition. This response was partly dependent on CD4+ T cells. CD8+ T cell response induced by BCG-OVA, but not LM-OVA, was highly dependent on pathogen persistence to compensate for the weak initial CD8+ T cell priming. Despite a stronger initial T cell response with LM-OVA, BCG-OVA provided more effective tumor (B16OVA) control at both local and distal sites due to the induction of a persistently activated acquired, and a more potent innate, immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.168.11.5737","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:43:29Z","timestamp":1398120209000},"page":"5737-5745","source":"Crossref","is-referenced-by-count":73,"title":["Multiple Mechanisms Compensate to Enhance Tumor-Protective CD8+ T Cell Response in the Long-Term Despite Poor CD8+ T Cell Priming Initially: Comparison Between an Acute Versus a Chronic Intracellular Bacterium Expressing a Model Antigen"],"prefix":"10.1093","volume":"168","author":[{"given":"Renu","family":"Dudani","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Chapdelaine","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"van Faassen","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean K","family":"Smith","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash","family":"Sad","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council , Ottawa, Ontario ,","place":["Canada"]},{"name":"Department of Biochemistry, Microbiology, and Immunology, University of Ottawa , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"key":"2026020208173430600_R1","first-page":"639","volume-title":"J. 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