{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:22:10Z","timestamp":1792430530035,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although deficiencies in the NKT cell population have been observed in multiple sclerosis and mouse strains susceptible to experimental autoimmune encephalomyelitis (EAE), little is known about the function of these cells in CNS autoimmunity. In this work we report that TCR V\u03b114-J\u03b1281 transgenic nonobese diabetic mice, which are enriched in CD1d-restricted NKT cells, are protected from EAE. The protection is associated with a striking inhibition of Ag-specific IFN-\u03b3 production in the spleen, implying modulation of the encephalitogenic Th1 response. This modulation is independent of IL-4 because IL-4-deficient V\u03b114-J\u03b1281 mice are still protected against EAE and independent of NKT cell-driven Th1 to Th2 deviation, because no increased autoantigen-specific Th2 response was observed in immunized V\u03b114-J\u03b1281 transgenic mice. Our findings indicate that enrichment and\/or stimulation of CD1d-dependent NKT cells may be used as a novel strategy to treat CNS autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.168.12.6007","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T22:38:18Z","timestamp":1398206298000},"page":"6007-6011","source":"Crossref","is-referenced-by-count":117,"title":["Cutting Edge: V\u03b114-J\u03b1281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice"],"prefix":"10.1093","volume":"168","author":[{"given":"Lennart T","family":"Mars","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 546, Ho\u0302pital Pitie\u0301-Salpetriere , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ve\u0301ronique","family":"Laloux","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 25, Ho\u0302pital Necker, and Unite\u0301 561, Ho\u0302pital Saint Vincent de Paul , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Goude","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 546, Ho\u0302pital Pitie\u0301-Salpetriere , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Desbois","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 546, Ho\u0302pital Pitie\u0301-Salpetriere , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhadi","family":"Saoudi","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 563, Ho\u0302pital Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Kaer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Howard Hughes Medical Institute, Vanderbilt University School of Medicine , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Lassmann","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u0301","family":"Herbelin","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 25, Ho\u0302pital Necker, and Unite\u0301 561, Ho\u0302pital Saint Vincent de Paul , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agne\u0300s","family":"Lehuen","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 25, Ho\u0302pital Necker, and Unite\u0301 561, Ho\u0302pital Saint Vincent de Paul , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland S","family":"Liblau","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 546, Ho\u0302pital Pitie\u0301-Salpetriere , Paris ,","place":["France"]},{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 563, Ho\u0302pital Purpan , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,6,15]]},"reference":[{"key":"2026020208204556100_R1","first-page":"676","volume-title":"Curr. 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