{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:05:48Z","timestamp":1778119548364,"version":"3.51.4"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Borrelia burgdorferi, the Lyme disease agent, causes joint inflammation in an experimental murine model. Inflammation occurs, in part, due to the ability of B. burgdorferi to induce the production of proinflammatory cytokines and a strong CD4+ T helper type 1 response. The mechanisms by which spirochetes induce these responses are not completely known, although transcription factors, such as NF-\u03baB in phagocytic cells, initiate the proinflammatory cytokine burst. We show here that the mitogen-activated protein (MAP) kinase of 38 kDa (p38 MAP kinase) is involved in the proinflammatory cytokine production elicited by B. burgdorferi Ags in phagocytic cells and the development of murine Lyme arthritis. B. burgdorferi Ags activated p38 MAP kinase in vitro, and the use of a specific inhibitor repressed the spirochete-induced production of TNF-\u03b1. The infection of mice that are deficient for a specific upstream activator of the kinase, MAP kinase kinase 3, resulted in diminished proinflammatory cytokine production and the development of arthritis, without compromising the ability of CD4+ T cells to respond to borrelial Ags or the production of specific Abs. Overall, these data indicated that the p38 MAP kinase pathway plays an important role in B. burgdorferi-elicited inflammation and point to potential new therapeutic approaches to the treatment of inflammation induced by the spirochete.<\/jats:p>","DOI":"10.4049\/jimmunol.168.12.6352","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T22:38:18Z","timestamp":1398206298000},"page":"6352-6357","source":"Crossref","is-referenced-by-count":31,"title":["Murine Lyme Arthritis Development Mediated by p38 Mitogen-Activated Protein Kinase Activity"],"prefix":"10.1093","volume":"168","author":[{"given":"Juan","family":"Anguita","sequence":"first","affiliation":[{"name":"Department of Biology, University of North Carolina , Charlotte, NC 28223"},{"name":"Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W","family":"Barthold","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California , Davis, CA 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafal","family":"Persinski","sequence":"additional","affiliation":[{"name":"Department of Biology, University of North Carolina , Charlotte, NC 28223"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N","family":"Hedrick","sequence":"additional","affiliation":[{"name":"Department of Biology, University of North Carolina , Charlotte, NC 28223"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy A","family":"Huy","sequence":"additional","affiliation":[{"name":"Department of Biology, University of North Carolina , Charlotte, NC 28223"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger J","family":"Davis","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School and Howard Hughes Medical Institute , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A","family":"Flavell","sequence":"additional","affiliation":[{"name":"Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,6,15]]},"reference":[{"key":"2026020209033246600_R1","first-page":"115","volume-title":"N. 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