{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:03:38Z","timestamp":1772895818131,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The immune response against the intracellular bacterium Listeria monocytogenes involves both CD4+ and CD8+ T cells. We used the MHC class II-presented peptide listeriolysin189\u2013201 to characterize the organ-specific CD4+ T cell response during infection. Systemic listeriosis resulted in a strong peptide-specific CD4+ T cell response with frequencies of 1\/100 and 1\/30 CD4+ splenocytes at the peak of primary and secondary response, respectively. This response was not restricted to lymphoid organs, because we detected specific CD4+ T cells in all tissues analyzed. However, the tissue distribution of the T cell response was dependent on the route of infection. After i.v. infection, the strongest CD4+ T cell response and the highest levels of memory cells were observed in spleen and liver, the major sites of L. monocytogenes replication. After oral infection, we detected a strong response in the liver, the lamina propria, and the intestinal epithelium. These tissues also harbored the highest frequencies of listeriolysin189\u2013201-specific CD4+ memory T cells 5\u20138 wk post oral infection. Our results show that kinetics and magnitude of the CD4+ T cell response and the accumulation of CD4+ memory T cells depend on the route of infection and are regulated in a tissue-specific way.<\/jats:p>","DOI":"10.4049\/jimmunol.168.12.6382","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T22:38:18Z","timestamp":1398206298000},"page":"6382-6387","source":"Crossref","is-referenced-by-count":62,"title":["Organ-Specific CD4+ T Cell Response During\n                    <i>Listeria monocytogenes<\/i>\n                    Infection"],"prefix":"10.1093","volume":"168","author":[{"given":"Mischo","family":"Kursar","sequence":"first","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Bonhagen","sequence":"additional","affiliation":[{"name":"Deutsches Rheumaforschungszentrum , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Ko\u0308hler","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kamradt","sequence":"additional","affiliation":[{"name":"Deutsches Rheumaforschungszentrum , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan H E","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Willi","family":"Mittru\u0308cker","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,6,15]]},"reference":[{"key":"2026020209051211300_R1","first-page":"129","volume-title":"Annu. 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