{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:04:04Z","timestamp":1790384644746,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To elucidate potential roles of IL-15 in the maintenance of memory CD8+ T cells, we followed the fate of Ag-specific CD8+ T cells directly visualized with MHC class I tetramers coupled with listeriolysin O (LLO)91\u201399 in IL-15 transgenic (Tg) mice after Listeria monocytogenes infection. The numbers of LLO91\u201399-positive memory CD8+ T cells were significantly higher at 3 and 6 wk after infection than those in non-Tg mice. The LLO91\u201399-positive CD8+ T cells produced IFN-\u03b3 in response to LLO91\u201399, and an adoptive transfer of CD8+ T cells from IL-15 Tg mice infected with L. monocytogenes conferred a higher level of resistance against L. monocytogenes in normal mice. The CD44+CD8+ T cells from infected IL-15 Tg mice expressed the higher level of Bcl-2. Transferred CD44+CD8+ T cells divided more vigorously in naive IL-15 Tg mice than in non-Tg mice. These results suggest that IL-15 plays an important role in long-term maintenance of Ag-specific memory CD8+ T cells following microbial exposure via promotion of cell survival and homeostatic proliferation.<\/jats:p>","DOI":"10.4049\/jimmunol.168.3.1198","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:45Z","timestamp":1398024525000},"page":"1198-1203","source":"Crossref","is-referenced-by-count":85,"title":["Overexpression of IL-15 In Vivo Increases Antigen-Driven Memory CD8+ T Cells Following a Microbe Exposure"],"prefix":"10.1093","volume":"168","author":[{"given":"Toshiki","family":"Yajima","sequence":"first","affiliation":[{"name":"Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine , Nagoya ,","place":["Japan"]},{"name":"First Department of Surgery, Gunma University School of Medicine , Maebashi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Ishimitsu","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketo","family":"Watase","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H","family":"Busch","sequence":"additional","affiliation":[{"name":"Sections of Infectious Diseases and Immunology, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G","family":"Pamer","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Immunology Program, Sloan-Kettering Institue , New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Gunma University School of Medicine , Maebashi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunobu","family":"Yoshikai","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,2,1]]},"reference":[{"key":"2026020208165788200_R1","first-page":"221","volume-title":"Annu. 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