{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:02:33Z","timestamp":1791147753289,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In humans, the circulating pool of mycobacteria-reactive V\u03b39V\u03b42+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets of V\u03b39V\u03b42+ T cells could be identified on the basis of CD27 expression in immunocompetent adults, showing that functionally differentiated \u03b3\u03b4 T cells have lost CD27 expression. In contrast, the CD27\u2212CD45RA\u2212V\u03b39V\u03b42+ T cell subset of effector cells was absent in cord blood cells from healthy newborns and lacking in the peripheral blood from HIV-infected patients. Moreover, circulating V\u03b39V\u03b42+ T cell effectors were significantly reduced in patients with acute pulmonary tuberculosis, resulting in a reduced frequency of IFN-\u03b3-producing cells after stimulation with nonpeptidic mycobacterial ligands. These observations indicate that monitoring and boosting \u03b3\u03b4 T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease.<\/jats:p>","DOI":"10.4049\/jimmunol.168.3.1484","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:45Z","timestamp":1398024525000},"page":"1484-1489","source":"Crossref","is-referenced-by-count":94,"title":["Lack of CD27\u2212CD45RA\u2212V\u03b39V\u03b42+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis"],"prefix":"10.1093","volume":"168","author":[{"given":"Cristiana","family":"Gioia","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pathology-Immunopathology, \u201cPadiglione Del Vecchio,\u201d National Institute for Infectious Diseases, \u201cLazzaro Spallanzani,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Agrati","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology-Immunopathology, \u201cPadiglione Del Vecchio,\u201d National Institute for Infectious Diseases, \u201cLazzaro Spallanzani,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Casetti","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology-Immunopathology, \u201cPadiglione Del Vecchio,\u201d National Institute for Infectious Diseases, \u201cLazzaro Spallanzani,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Cairo","sequence":"additional","affiliation":[{"name":"Research Center, \u201cSan Pietro-Fatebenefratelli\u201d , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Borsellino","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimmunology, \u201cSanta Lucia Foundation,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Battistini","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimmunology, \u201cSanta Lucia Foundation,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Mancino","sequence":"additional","affiliation":[{"name":"Research Center, \u201cSan Pietro-Fatebenefratelli\u201d , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Goletti","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology-Immunopathology, \u201cPadiglione Del Vecchio,\u201d National Institute for Infectious Diseases, \u201cLazzaro Spallanzani,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Colizzi","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome, \u201cTor Vergata\u201d , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo P","family":"Pucillo","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology-Immunopathology, \u201cPadiglione Del Vecchio,\u201d National Institute for Infectious Diseases, \u201cLazzaro Spallanzani,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Poccia","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology-Immunopathology, \u201cPadiglione Del Vecchio,\u201d National Institute for Infectious Diseases, \u201cLazzaro Spallanzani,\u201d Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,2,1]]},"reference":[{"key":"2026020208164942800_R1","first-page":"1331","volume-title":"J. 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