{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:31:35Z","timestamp":1770085895088,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IFN-\u03b3 is an essential component of the early Listeria monocytogenes-specific immune response, and is also an important regulator of Ag processing and presentation. Ag presentation is required for the induction and also the effector function of antimicrobial T cells. To evaluate the effect of IFN-\u03b3 on bacterial Ag presentation in vivo, macrophages and dendritic cells were separated from L. monocytogenes-infected tissues and analyzed with peptide-specific CD4 and CD8 T cell lines in a sensitive ELISPOT-based ex vivo Ag presentation assay. The comparison of professional APCs isolated from infected IFN-\u03b3-deficient and wild-type mice revealed different peptide presentation patterns of L. monocytogenes-derived CD8 T cell epitopes, while the presentation pattern of CD4 T cell epitopes remained unchanged. The further in vitro analysis of the generation of CD8 T cell epitopes revealed a peptide-specific effect of IFN-\u03b3 on MHC class I-restricted Ag presentation. These results show that despite this modulation of the Ag presentation pattern of CD8 T cell epitopes, IFN-\u03b3 is not generally required for the MHC class I- and MHC class II-restricted presentation of L. monocytogenes-derived antigenic peptides by professional APCs in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.168.4.1854","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:56:53Z","timestamp":1398031013000},"page":"1854-1860","source":"Crossref","is-referenced-by-count":15,"title":["Efficient In Vivo Presentation of\n                    <i>Listeria monocytogenes<\/i>\n                    - Derived CD4 and CD8 T Cell Epitopes in the Absence of IFN-\u03b3"],"prefix":"10.1093","volume":"168","author":[{"given":"Mojca","family":"S\u030ckoberne","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Fakulta\u0308t fu\u0308r Klinische Medizin Mannheim der Universita\u0308t Heidelberg , Mannheim ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Geginat","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Fakulta\u0308t fu\u0308r Klinische Medizin Mannheim der Universita\u0308t Heidelberg , Mannheim ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,2,15]]},"reference":[{"key":"2026020209015304100_R1","first-page":"749","volume-title":"Annu. 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