{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:56:17Z","timestamp":1791122177243,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The complement system\u2014particularly component C3\u2014has been demonstrated to be a key link between innate and adaptive immunity. The trimolecular complex of complement receptor type 2 (CR2), CD19, and CD81 is known to promote B cell activation when coligated with the B cell Ag receptor. In the present study, we aimed to elucidate the role of human complement receptor type 1 (CR1), the other C3-receptor on B cells. As ligand, aggregated C3 and aggregated C3(H2O), i.e., multimeric \u201cC3b-like C3\u201d, are used, which bind to CR1, but not to CR2. In experiments studying the functional consequences of CR1-clustering, the multimeric ligand is shown to inhibit the proliferation of tonsil B cells activated with a suboptimal dose of anti-IgM F(ab\u2032)2. Importantly, this inhibitory activity also occurs in the presence of the costimulatory cytokines IL-2 and IL-15. The anti-IgM-induced transient increase in the concentration of intracellular free Ca2+ and phosphorylation of several cytoplasmic proteins are strongly reduced in the presence of the CR1 ligand. Data presented indicate that CR1 has a negative regulatory role in the B cell Ag receptor mediated activation of human B lymphocytes.<\/jats:p>","DOI":"10.4049\/jimmunol.168.6.2782","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:31:13Z","timestamp":1398040273000},"page":"2782-2788","source":"Crossref","is-referenced-by-count":80,"title":["Complement Receptor Type 1 (CD35) Mediates Inhibitory Signals in Human B Lymphocytes"],"prefix":"10.1093","volume":"168","author":[{"given":"Miha\u0301ly","family":"Jo\u0301zsi","sequence":"first","affiliation":[{"name":"Department of Immunology and Research Group of the Hungarian Academy of Sciences, Eo\u0308tvo\u0308s Lora\u0301nd University , Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0301zsef","family":"Prechl","sequence":"additional","affiliation":[{"name":"Department of Immunology and Research Group of the Hungarian Academy of Sciences, Eo\u0308tvo\u0308s Lora\u0301nd University , Budapest ,","place":["Hungary"]},{"name":"Research Group of the Hungarian Academy of Sciences, Eo\u0308tvo\u0308s Lora\u0301nd University , Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsa","family":"Bajtay","sequence":"additional","affiliation":[{"name":"Department of Immunology and Research Group of the Hungarian Academy of Sciences, Eo\u0308tvo\u0308s Lora\u0301nd University , Budapest ,","place":["Hungary"]},{"name":"Research Group of the Hungarian Academy of Sciences, Eo\u0308tvo\u0308s Lora\u0301nd University , Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Erdei","sequence":"additional","affiliation":[{"name":"Department of Immunology and Research Group of the Hungarian Academy of Sciences, Eo\u0308tvo\u0308s Lora\u0301nd University , Budapest ,","place":["Hungary"]},{"name":"Research Group of the Hungarian Academy of Sciences, Eo\u0308tvo\u0308s Lora\u0301nd University , Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,3,15]]},"reference":[{"key":"2025032712351802400_R1","first-page":"50","volume-title":"Science","year":"1996"},{"key":"2025032712351802400_R2","first-page":"4","volume-title":"Curr. 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