{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:12:59Z","timestamp":1791231179873,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Using STAT6\u2212\/\u2212 BALB\/c mice, we analyzed the role of STAT6-induced Th2 response in determining the outcome of murine cysticercosis caused by the helminth parasite Taenia crassiceps. After T. crassiceps infection, wild-type BALB\/c mice developed a strong Th2-like response; produced high levels of IgG1, IgE, IL-4, as well as IL-13; and remained susceptible to T. crassiceps. In contrast, similarly infected STAT6\u2212\/\u2212 mice mounted a strong Th1-like response; produced high levels of IgG2a, IL-12, IFN-\u03b3, as well as nitric oxide; and efficiently controlled T. crassiceps infection. These findings demonstrate that Th2-like response induced via STAT6-mediated signaling pathway mediates susceptibility to T. crassiceps and, furthermore, that unlike the case in most helminths, immunity against T. crassiceps is mediated by a Th1-like rather than Th2-like response.<\/jats:p>","DOI":"10.4049\/jimmunol.168.7.3135","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:54Z","timestamp":1398024534000},"page":"3135-3139","source":"Crossref","is-referenced-by-count":64,"title":["Cutting Edge: Susceptibility to the Larval Stage of the Helminth Parasite\n                    <i>Taenia crassiceps<\/i>\n                    Is Mediated by Th2 Response Induced Via STAT6 Signaling"],"prefix":"10.1093","volume":"168","author":[{"given":"Miriam","family":"Rodriguez-Sosa","sequence":"first","affiliation":[{"name":"Department of Immunology, Instituto Nacional de Cardiologia \u201cIgnacio Chavez,\u201d \u00a0 Mexico ,","place":["D.F. Mexico"]},{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"David","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Bojalil","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto Nacional de Cardiologia \u201cIgnacio Chavez,\u201d \u00a0 Mexico ,","place":["D.F. 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