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This study uses knockout mice to demonstrate a novel function for the heterotrimeric G protein, Gq, in the regulation of pulmonary eosinophil recruitment. In the absence of Gq signaling, eosinophils failed to accumulate in the lungs following allergen challenge. These studies demonstrate that the inhibition of eosinophil accumulation in the airways is attributed to the failure of hemopoietically derived cells to elaborate GM-CSF in the airways. The data suggest that activation of a Gq-coupled receptor(s) on resident leukocytes in the lung elicits expression of GM-CSF, which, in turn, is required for allergen-induced pulmonary eosinophilia, identifying a novel pathway of eosinophil-associated effector functions leading to pulmonary pathology in diseases such as asthma.<\/jats:p>","DOI":"10.4049\/jimmunol.168.7.3543","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:54Z","timestamp":1398024534000},"page":"3543-3549","source":"Crossref","is-referenced-by-count":18,"title":["Gq Signaling Is Required for Allergen-Induced Pulmonary Eosinophilia"],"prefix":"10.1093","volume":"168","author":[{"given":"Michael T","family":"Borchers","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine, Mayo Clinic , Scottsdale AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J","family":"Justice","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Mayo Clinic , Scottsdale AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Ansay","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Mayo Clinic , Scottsdale AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Mancino","sequence":"additional","affiliation":[{"name":"Division of Biology, California Institute of Technology , Pasadena, CA 91125"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P","family":"McGarry","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Mayo Clinic , Scottsdale AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Crosby","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Mayo Clinic , Scottsdale AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin I","family":"Simon","sequence":"additional","affiliation":[{"name":"Division of Biology, California Institute of Technology , Pasadena, CA 91125"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Mayo Clinic , Scottsdale AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Mayo Clinic , Scottsdale AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"2026020209090009100_R1","first-page":"255","volume-title":"Annu. 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