{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:27:35Z","timestamp":1778588855237,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the role of complement in lupus nephritis, we used MRL\/lpr mice and a transgene overexpressing a soluble complement regulator, soluble CR1-related gene\/protein y (sCrry), both systemically and in kidney. Production of sCrry in sera led to significant complement inhibition in Crry-transgenic mice relative to littermate transgene negative controls. This complement inhibition with sCrry conferred a survival advantage to MRL\/lpr mice. In a total of 154 animals, 42.5% transgene-negative animals had impaired renal function (blood urea nitrogen &amp;gt; 50 mg\/dl) compared with 16.4% mice with the sCrry-producing transgene (p &amp;lt; 0.001). In those animals that died spontaneously, MRL\/lpr mice with the sCrry-producing transgene did not die of renal failure, while those without the transgene did (blood urea nitrogen values of 46.6 \u00b1 9 and 122 \u00b1 29 mg\/dl in transgene-positive and transgene-negative animals, respectively; p &amp;lt; 0.001). Albuminuria was reduced in those transgenic animals in which sCrry expression was maximally stimulated (urinary albumin\/creatinine = 12.4 \u00b1 4.3 and 36.9 \u00b1 7.7 in transgene-positive and transgene-negative animals, respectively; p &amp;lt; 0.001). As expected in the setting of chronic complement inhibition, there was less C3 deposition in glomeruli of sCrry-producing transgenic mice compared with transgene-negative animals. In contrast, there was no effect on glomerular IgG deposition, levels of anti-dsDNA Ab and rheumatoid factor, or spleen weights between the two groups. Thus, long-term complement inhibition reduces renal disease in MRL\/lpr mice, which translates into improved survival. MRL\/lpr mice in which complement is inhibited still have spontaneous mortality, yet this is not from renal disease.<\/jats:p>","DOI":"10.4049\/jimmunol.168.7.3601","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:54Z","timestamp":1398024534000},"page":"3601-3607","source":"Crossref","is-referenced-by-count":72,"title":["Transgenic Expression of a Soluble Complement Inhibitor Protects Against Renal Disease and Promotes Survival in MRL\/\n                    <i>lpr<\/i>\n                    Mice"],"prefix":"10.1093","volume":"168","author":[{"given":"Lihua","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Nephrology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A","family":"Boackle","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian M","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick N","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierce","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessy J","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall K","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Culhane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V Michael","family":"Holers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Quigg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"2026020209090673600_R1","first-page":"917","volume-title":"Fundamental Immunology","year":"1993"},{"key":"2026020209090673600_R2","first-page":"1058","volume-title":"N. Engl. J. Med.","year":"2001"},{"key":"2026020209090673600_R3","first-page":"244","volume-title":"Immunol. Res.","year":"1993"},{"key":"2026020209090673600_R4","first-page":"201","volume-title":"Adv. Immunol.","year":"1996"},{"key":"2026020209090673600_R5","first-page":"161","volume-title":"Annu. Rev. Immunol.","year":"1988"},{"key":"2026020209090673600_R6","first-page":"1381","volume-title":"Eur. J. Immunol.","year":"1993"},{"key":"2026020209090673600_R7","first-page":"151","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020209090673600_R8","first-page":"123","volume-title":"Crit. Rev. Clin. Lab. Sci.","year":"1986"},{"key":"2026020209090673600_R9","first-page":"1055","volume-title":"Immunologic Renal Diseases","year":"1997"},{"key":"2026020209090673600_R10","first-page":"1140","volume-title":"N. Engl. J. Med.","year":"2001"},{"key":"2026020209090673600_R11","first-page":"56","volume-title":"Nat. Genet.","year":"1998"},{"key":"2026020209090673600_R12","first-page":"S-13","volume-title":"Kidney Int.","year":"1993"},{"key":"2026020209090673600_R13","first-page":"1333","volume-title":"Arthritis Rheum.","year":"1995"},{"key":"2026020209090673600_R14","first-page":"243","volume-title":"Annu. Rev. Immunol.","year":"1991"},{"key":"2026020209090673600_R15","first-page":"121","volume-title":"Systemic Lupus Erythematosus","year":"1992"},{"key":"2026020209090673600_R16","first-page":"157","volume-title":"Immunol. Rev.","year":"1995"},{"key":"2026020209090673600_R17","first-page":"339","volume-title":"Dubois\u2019 Lupus Erythematosus","year":"1997"},{"key":"2026020209090673600_R18","first-page":"314","volume-title":"Nature","year":"1992"},{"key":"2026020209090673600_R19","first-page":"1756","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2026020209090673600_R20","first-page":"269","volume-title":"Adv. Immunol.","year":"1985"},{"key":"2026020209090673600_R21","first-page":"1779","volume-title":"J. Exp. Med.","year":"1981"},{"key":"2026020209090673600_R22","first-page":"560","volume-title":"J. Clin. Invest.","year":"1983"},{"key":"2026020209090673600_R23","first-page":"494","volume-title":"Lab. Invest.","year":"1993"},{"key":"2026020209090673600_R24","first-page":"63","volume-title":"Experientia Suppl.","year":"1987"},{"key":"2026020209090673600_R25","first-page":"1321","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020209090673600_R26","first-page":"245","volume-title":"Immunopharmacology","year":"1999"},{"key":"2026020209090673600_R27","first-page":"320","volume-title":"Kidney Int.","year":"1998"},{"key":"2026020209090673600_R28","first-page":"4553","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020209090673600_R29","first-page":"1125","volume-title":"Am. J. Pathol.","year":"1989"},{"key":"2026020209090673600_R30","first-page":"1676","volume-title":"J. Clin. 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