{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:39:51Z","timestamp":1770086391628,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lupus-associated anti-DNA Abs display features of Ag selection, yet the triggering Ag in the disease is unknown. We previously demonstrated that the peptide DWEYSVWLSN is bound by a pathogenic anti-DNA Ab, and that immunization of nonautoimmune mice with this peptide induces autoantibodies and renal Ig deposition. To elucidate differences in the induced B cell responses in mice genetically predisposed to autoimmunity, young (NZB \u00d7 NZW)F1 mice were immunized with this peptide DNA mimetope. DWEYSVWLSN-immunized mice had significantly increased IgG anti-dsDNA, anti-laminin, and anti-cardiolipin Ab titers compared with controls. In addition, glomerular histopathology in the form of endocapillary disease and crescent formation was markedly more severe in DWEYSVWLSN-immunized mice. Analysis of mAbs from DWEYSVWLSN-immunized mice revealed that anti-peptide Abs were often cross-reactive with DNA. Genetic elements used in the Ab response in immunized mice were homologous to those used in the spontaneous anti-DNA response in (NZB \u00d7 NZW)F1 mice, as well as in other, experimentally induced anti-DNA Abs. Our results indicate that peptide immunization can induce a molecular genetic response common to a variety of stimuli that break tolerance to mammalian dsDNA. Based on the similarity between spontaneously arising anti-DNA Abs and several types of induced anti-DNA Abs, we suggest that there may be more than a single Ag that can trigger systemic lupus erythematosus.<\/jats:p>","DOI":"10.4049\/jimmunol.168.7.3617","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:08:54Z","timestamp":1398024534000},"page":"3617-3626","source":"Crossref","is-referenced-by-count":22,"title":["A Peptide DNA Surrogate Accelerates Autoimmune Manifestations and Nephritis in Lupus-Prone Mice"],"prefix":"10.1093","volume":"168","author":[{"given":"Erik","family":"Beger","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bisram","family":"Deocharan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Edelman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Epidemiology and Social Medicine, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryna","family":"Erblich","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Epidemiology and Social Medicine, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaim","family":"Putterman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Albert Einstein College of Medicine , Bronx, NY 10461"},{"name":"Department of Microbiology and Immunology, Epidemiology and Social Medicine, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"2026020209071771600_R1","first-page":"167","volume-title":"Adv. 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