{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:41:53Z","timestamp":1770086513374,"version":"3.49.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD154 is transiently expressed by activated T cells and interacts with CD40 on B cells, dendritic cells, macrophages, and monocytes. This costimulatory receptor-ligand couple seems decisive in Ag-driven immune responses but may be differentially involved in type 1 vs type 2 responses. We studied the importance of CD40-CD154 in both responses using the reporter Ag popliteal lymph node assay in which selectively acting drugs generate clearly polarized type 1 (streptozotocin) or type 2 (D-penicillamine, diphenylhydantoin) responses to a constant coinjected Ag in the same mouse strain. Treatment of mice with anti-CD154 reduced characteristic immunological parameters in type 2 responses (B and CD4+ T cell proliferation, IgG1 and IgE Abs, and IL-4 secretion) and only slightly affected the type 1 response (small decrease in IFN-\u03b3 production, influx of CD11c+ and F4\/80+ cells, and prevention of architectural disruption of the lymph node, but no effect on IgG2a Ab and TNF-\u03b1 secretion or B and CD4+ T cell proliferation). The findings indicate that the CD40-CD154 costimulatory interaction is a prerequisite in drug-induced type 2 responses and is only marginally involved in type 1 responses. The observed expression patterns of CD80 and CD86 on different APC (B cells in type 2 and dendritic cells in type 1) may be responsible for this discrepancy.<\/jats:p>","DOI":"10.4049\/jimmunol.168.8.3747","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:10:41Z","timestamp":1398125441000},"page":"3747-3754","source":"Crossref","is-referenced-by-count":24,"title":["Selective Requirement for CD40-CD154 in Drug-Induced Type 1 Versus Type 2 Responses to Trinitrophenyl-Ovalbumin"],"prefix":"10.1093","volume":"168","author":[{"given":"Stefan","family":"Nierkens","sequence":"first","affiliation":[{"name":"Department of Immunotoxicology, Institute for Risk Assessment Sciences, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"van Helden","sequence":"additional","affiliation":[{"name":"Department of Immunotoxicology, Institute for Risk Assessment Sciences, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Bol","sequence":"additional","affiliation":[{"name":"Department of Immunotoxicology, Institute for Risk Assessment Sciences, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Bleumink","sequence":"additional","affiliation":[{"name":"Department of Immunotoxicology, Institute for Risk Assessment Sciences, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"van Kooten","sequence":"additional","affiliation":[{"name":"Immunology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Ramdien-Murli","sequence":"additional","affiliation":[{"name":"Tanox Pharma B.V. , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Boon","sequence":"additional","affiliation":[{"name":"Tanox Pharma B.V. , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Pieters","sequence":"additional","affiliation":[{"name":"Department of Immunotoxicology, Institute for Risk Assessment Sciences, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,4,15]]},"reference":[{"key":"2026020209080637700_R1","first-page":"3506","volume-title":"J. 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