{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:53:44Z","timestamp":1770479624380,"version":"3.49.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We propose a classification of human CD4+CD45RO+ memory T cells into three new subsets based on cell surface expression levels of CD43. The first subset consists of cells whose CD43 expression is relatively high; this subset also contains the highest proportion of recall Ag-reactive precursors, and its constituent cells respond far more strongly than cells in either of the other subsets to immobilized CD3 Ab in addition to secreting substantially more IFN-\u03b3 and IL-4. Cells of the second subset express similar levels of CD43 to naive cells, and they also respond weakly to TCR-mediated stimuli as judged by either their ability to proliferate or capacity for cytokine production. The third subsets consists of cells whose CD43 expression levels are clearly down-regulated; its cells appear to be anergic to TCR-mediated stimuli, and when examined ex vivo many of them appear to be undergoing either spontaneous apoptosis via a caspase-independent pathway or Fas-mediated apoptosis via a caspase-dependent pathway, even in the resting state. An analysis of telomere lengths revealed that the typical telomere of a cell in the second subset was significantly longer than the typical telomere in the first or third subset. Taken together, these results appear to indicate that CD4+CD45RO+ T cells fall into three functionally differing subsets, one being a subset of cells with fully matured memory phenotype, a second being a less mature subset of cells that retain longer telomeres and whose memory functionality is marginal, and a third consisting of anergic cells that give every appearance of being death-prone and\/or in the process of dying.<\/jats:p>","DOI":"10.4049\/jimmunol.169.1.39","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:33:01Z","timestamp":1398025981000},"page":"39-48","source":"Crossref","is-referenced-by-count":18,"title":["Memory Functions and Death Proneness in Three CD4+CD45RO+ Human T Cell Subsets"],"prefix":"10.1093","volume":"169","author":[{"given":"Takaaki","family":"Ohara","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, Department of Radiobiology, Radiation Effects Research Foundation , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Radiobiology, Radiation Effects Research Foundation , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Radiobiology, Radiation Effects Research Foundation , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Radiobiology, Radiation Effects Research Foundation , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Tsuyama","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Radiobiology, Radiation Effects Research Foundation , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Radiobiology, Radiation Effects Research Foundation , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishi","family":"Kyoizumi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Radiobiology, Radiation Effects Research Foundation , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"2026020208192202600_R1","first-page":"49","volume-title":"Annu. 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