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In the present study a role of galectin-9 in the interaction between eosinophils and fibroblasts was investigated using a human lung fibroblast cell line, HFL-1. RT-PCR, real-time PCR, and Western blot analyses revealed that both galectin-9 mRNA and protein in HFL-1 cells were up-regulated by IFN-\u03b3 stimulation. On the one hand, IL-4, known as a Th2 cytokine, did not affect the galectin-9 expression in HFL-1 cells. We further confirmed that IFN-\u03b3 up-regulated the expression of galectin-9 in primary human dermal fibroblasts. Flow cytometric analysis revealed that IFN-\u03b3 up-regulated surface galectin-9 expression on HFL-1 cells. Stimulation of HFL-1 cells with IFN-\u03b3 up-regulated adhesion of eosinophils, but not neutrophils, to HFL-1 cells. This adherence of eosinophils to HFL-1 cells was inhibited by both lactose and anti-galectin-9 Ab. These findings demonstrate that IFN-\u03b3-induced galectin-9 expression in fibroblasts mediates eosinophil adhesion to the cells, suggesting a crucial role of galectin-9 in IFN-\u03b3-stimulated fibroblasts as a physiological modulator at the inflammatory sites.<\/jats:p>","DOI":"10.4049\/jimmunol.169.10.5912","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:04:08Z","timestamp":1398024248000},"page":"5912-5918","source":"Crossref","is-referenced-by-count":122,"title":["Selective Eosinophil Adhesion to Fibroblast Via IFN-\u03b3-Induced Galectin-9"],"prefix":"10.1093","volume":"169","author":[{"given":"Hirofumi","family":"Asakura","sequence":"first","affiliation":[{"name":"Radiology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kashio","sequence":"additional","affiliation":[{"name":"Immunology and Immunopathology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Immunology and Immunopathology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Seki","sequence":"additional","affiliation":[{"name":"Immunology and Immunopathology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Dai","sequence":"additional","affiliation":[{"name":"Perinatology and Gynecology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Shirato","sequence":"additional","affiliation":[{"name":"Immunology and Immunopathology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad J","family":"Abedin","sequence":"additional","affiliation":[{"name":"Immunology and Immunopathology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Immunology and Immunopathology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Nishi","sequence":"additional","affiliation":[{"name":"Endocrinology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaatsu","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine , Hirosaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Saita","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Kumamoto University School of Medicine , Kumamoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Toyama","sequence":"additional","affiliation":[{"name":"Radiology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Takashima","sequence":"additional","affiliation":[{"name":"Radiology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Endocrinology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoomi","family":"Ohkawa","sequence":"additional","affiliation":[{"name":"Radiology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuomi","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Immunology and Immunopathology, Kagawa Medical University , Kagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,11,15]]},"reference":[{"key":"2026020209203626800_R1","first-page":"402","volume-title":"J. 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