{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:21:33Z","timestamp":1791116493862,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It has been proposed that expression of the chemokine receptor CCR7 represents a defining factor for nonpolarized central (CCR7+) and polarized effector memory (CCR7\u2212) T cells. In this study, we have tested this hypothesis using in vivo-activated T cells from P14 and SMARTA TCR-transgenic (tg) mice specific for MHC class I- and II-restricted epitopes of the lymphocytic choriomeningitis virus (LCMV) glycoprotein. CCR7 cell surface expression on TCR-tg cells was monitored with a CC chemokine ligand 19-Ig fusion protein. CC chemokine ligand 19-Ig staining separated TCR-tg cells activated by LCMV infection into CCR7\u2212 and CCR7+ effector\/memory T cell populations. Nonetheless, both T cell populations isolated from spleen and liver produced identical amounts of IFN-\u03b3 after short-term Ag stimulation. Furthermore, CCR7+ and CCR7\u2212 CD8 TCR-tg cells from LCMV-infected mice exhibited similar lytic activity against LCMV peptide-coated target cells. These results question the proposed concept of differential effector cell function of CCR7+ and CCR7\u2212 memory T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.169.2.638","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T02:54:25Z","timestamp":1398048865000},"page":"638-641","source":"Crossref","is-referenced-by-count":142,"title":["Cutting Edge: CCR7+ and CCR7\u2212 Memory T Cells Do Not Differ in Immediate Effector Cell Function"],"prefix":"10.1093","volume":"169","author":[{"given":"Heike","family":"Unsoeld","sequence":"first","affiliation":[{"name":"Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Krautwald","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Kiel , Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kunzendorf","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Kiel , Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,7,15]]},"reference":[{"key":"2025032905525008800_R1","first-page":"209","volume-title":"Adv. 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