{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:59:00Z","timestamp":1790247540818,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Murine Ag-specific CD8+ T cells express various NK markers and NK inhibitory receptors that have been proposed to modulate immune responses. Following acute infection of C57BL\/6 and BALB\/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8+ T cells expressed CD94\/NKG2. Only slight expression of Ly49A and Ly49C receptors was observed on NP396-specific T cells, while all NP396-specific T cells expressed the NKT cell marker U5A2-13 Ag. Expression of CD94\/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker. By means of cell sorting and quantitative PCR, we found that NP118-specific CD8+ T cells primarily express transcripts for inhibitory NKG2 receptor isoforms. CD94\/NKG2 expression was also observed on Ag-specific CD8+ T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8+ T cells following infection with viral or bacterial pathogens. Expression of CD94\/NKG2 on memory-specific CD8+ T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance. Furthermore, we found no evidence that CD94\/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation. Finally, down-regulation of CD94\/NKG2 was found to occur only during chronic LCMV infection. Altogether, this study suggests that CD94\/NKG2 expression is not necessarily correlated with inhibition of T cell function.<\/jats:p>","DOI":"10.4049\/jimmunol.169.2.693","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T02:54:25Z","timestamp":1398048865000},"page":"693-701","source":"Crossref","is-referenced-by-count":27,"title":["CD94\/NKG2 Expression Does Not Inhibit Cytotoxic Function of Lymphocytic Choriomeningitis Virus-Specific CD8+ T Cells"],"prefix":"10.1093","volume":"169","author":[{"given":"Joseph D","family":"Miller","sequence":"first","affiliation":[{"name":"Emory Vaccine Research Center, Emory University , Atlanta, GA 30329"},{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Peters","sequence":"additional","affiliation":[{"name":"Emory Vaccine Research Center, Emory University , Atlanta, GA 30329"},{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp E","family":"Oran","sequence":"additional","affiliation":[{"name":"Emory Vaccine Research Center, Emory University , Atlanta, GA 30329"},{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy W","family":"Beresford","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Altman","sequence":"additional","affiliation":[{"name":"Emory Vaccine Research Center, Emory University , Atlanta, GA 30329"},{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,7,15]]},"reference":[{"key":"2025032905530091300_R1","first-page":"3673","volume-title":"J. 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