{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:32:06Z","timestamp":1791221526155,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NK cells express several families of receptors that play central roles in target cell recognition. These NK cell receptors are also expressed by certain memory phenotype CD8+ T cells, and in some cases are up-regulated in T cells responding to viral infection. To determine how the profile of NK receptor expression changes in murine CD8+ T cells as they respond to intracellular pathogens, we used class I tetramer reagents to directly examine Ag-specific T cells during lymphocytic choriomeningitis virus and Listeria monocytogenes infections. We found that the majority of pathogen-specific CD8+ T cells initiated expression of the inhibitory CD94\/NKG2A heterodimer, the KLRG1 receptor, and a novel murine NK cell marker (10D7); conversely, very few Ag-specific T cells expressed Ly49 family members. The up-regulation of these receptors was independent of IL-15 and persisted long after clearance of the pathogen. The expression of CD94\/NKG2A was rapidly initiated in naive CD8+ T cells responding to peptide Ags in vitro and on many of the naive T cells that proliferate when transferred into lymphopenic (Rag-1\u2212\/\u2212) hosts. Thus, CD94\/NKG2A expression is a common consequence of CD8+ T cell activation. Binding of the CD94\/NKG2A receptor by its ligand (Qa-1b) did not significantly inhibit CD8+ T cell effector functions. However, expression of CD94 and NKG2A transgenes partially inhibited early events of T cell activation. These subtle effects suggest that CD94\/NKG2A-mediated inhibition of T cells may be limited to particular circumstances or may synergize with other receptors that are similarly up-regulated.<\/jats:p>","DOI":"10.4049\/jimmunol.169.3.1444","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T04:06:27Z","timestamp":1398139587000},"page":"1444-1452","source":"Crossref","is-referenced-by-count":123,"title":["Viral and Bacterial Infections Induce Expression of Multiple NK Cell Receptors in Responding CD8+ T Cells"],"prefix":"10.1093","volume":"169","author":[{"given":"Christopher W","family":"McMahon","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan J","family":"Zajac","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama , Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Corral","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna E","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Raulet","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"2025032905532714500_R1","first-page":"291","volume-title":"Annu. 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