{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:20:27Z","timestamp":1789867227636,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multiple sclerosis, a chronic inflammatory disease of the CNS, is characterized by immune-mediated demyelination. Many patients have a remitting-relapsing course of disease with exacerbations often following unrelated microbial illnesses. The relationship between the two events remains obscure. One possibility is that T cells specific for the inciting microbial pathogen are able to effect demyelination at a site of ongoing inflammation within the CNS. This possibility was examined in mice infected with mouse hepatitis virus, a well-described model of virus-induced demyelination. Using transgenic TCR\/recombination activation gene 2\u2212\/\u2212 mice with only non-mouse hepatitis virus-specific T cells, we show that CD8 T cells are able to cause demyelination in the absence of cognate Ag in the CNS, but only if specifically activated. These findings demonstrate a novel mechanism for immune-mediated neuropathology and show that activated CD8 T cells may serve as important mediators of bystander demyelination during times of infection, including in patients with multiple sclerosis.<\/jats:p>","DOI":"10.4049\/jimmunol.169.3.1550","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T04:06:27Z","timestamp":1398139587000},"page":"1550-1555","source":"Crossref","is-referenced-by-count":54,"title":["Bystander CD8 T Cell-Mediated Demyelination After Viral Infection of the Central Nervous System"],"prefix":"10.1093","volume":"169","author":[{"given":"Jodie S","family":"Haring","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lecia L","family":"Pewe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Perlman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pediatrics, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"2025032905531240600_R1","first-page":"1344","volume-title":"Science","year":"1998"},{"key":"2025032905531240600_R2","first-page":"998","volume-title":"Diabetes","year":"1992"},{"key":"2025032905531240600_R3","first-page":"99","volume-title":"Br. 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