{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:46:53Z","timestamp":1792676813460,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>M cells represent the primary route by which mucosal Ags are transported across the intestinal epithelium and delivered to underlying gut-associated lymphoid tissues. In rodents and rabbits, Peyer\u2019s patch M cells selectively bind and endocytose secretory IgA (SIgA) Abs. Neither the nature of the M cell IgR nor the domains of SIgA involved in this interaction are known. Using a mouse ligated ileal loop assay, we found that monoclonal IgA Abs with or without secretory component, but not IgG or IgM Abs, bound to the apical surfaces of Peyer\u2019s patch M cells, indicating that the receptor is specific for the IgA isotype. Human serum IgA and colostral SIgA also bound to mouse M cells. The asialoglycoprotein receptor or other lectin-like receptors were not detected on the apical surfaces of M cells. We used recombinant human IgA1 and human IgA2 Abs and domain swapped IgA\/IgG chimeras to determine that both domains C\u03b11 and C\u03b12 are required for IgA adherence to mouse Peyer\u2019s patch M cells. This distinguishes the M cell IgA receptor from CD89 (Fc\u03b1I), which binds domains C\u03b12-C\u03b13. Finally, we observed by immunofluorescence microscopy that some M cells in the human ileum are coated with IgA. Together these data suggest that mouse, and possibly human, M cells express an IgA-specific receptor on their apical surfaces that mediates the transepithelial transport of SIgA from the intestinal lumen to underlying gut-associated organized lymphoid tissues.<\/jats:p>","DOI":"10.4049\/jimmunol.169.4.1844","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:19:11Z","timestamp":1398032351000},"page":"1844-1851","source":"Crossref","is-referenced-by-count":199,"title":["Selective Adherence of IgA to Murine Peyer\u2019s Patch M Cells: Evidence for a Novel IgA Receptor"],"prefix":"10.1093","volume":"169","author":[{"given":"Nicholas J","family":"Mantis","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, and Gastrointestinal Cell Biology Laboratory, Children\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha C","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, and Gastrointestinal Cell Biology Laboratory, Children\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koteswara R","family":"Chintalacharuvu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California , Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Rey","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Ho\u0302pital Orthope\u0301dique , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise","family":"Corthe\u0301sy","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Ho\u0302pital Orthope\u0301dique , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian R","family":"Neutra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, and Gastrointestinal Cell Biology Laboratory, Children\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,8,15]]},"reference":[{"key":"2025032905533377100_R1","first-page":"311","volume-title":"Annu. 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