{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:52:09Z","timestamp":1790434329378,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-2 was originally identified as a potent T cell growth factor. It was subsequently demonstrated that IL-2 also exerts proapoptotic effects under certain conditions. Inactivation of IL-2 by gene targeting in mice showed that whereas IL-2 is not essential for the generation, clonal expansion, or differentiation of lymphocytes to effector cells, it has a unique role in preventing the accumulation of activated lymphocytes. IL-2\u2212\/\u2212 mice show lymphoadenopathy and autoimmune reactions, suggesting that the proapoptotic effects of IL-2 may predominate in vivo. In this study, we confirm that lymph nodes (LNs) are enlarged in IL-2\u2212\/\u2212 animals, but surprisingly, we found that their spleens are almost normal in size. Subsequent to this observation, we compare lymphocytes from LNs and spleens of IL-2\u2212\/\u2212 and IL-2+\/\u2212 animals to analyze molecular and cellular correlates of the immunopathological disorders found in IL-2-deficient mice. LN lymphocytes from IL-2\u2212\/\u2212 are selectively activated and show an enhanced survival capacity and an increased ability to proliferate in vitro when compared with LN cells from IL-2+\/\u2212 mice and splenocytes from IL-2\u2212\/\u2212 and IL-2+\/\u2212 mice. Because the apoptosis inhibitor FLIP has been shown in vitro to participate in the IL-2 control of activation-induced cell death, we analyze its expression in IL-2\u2212\/\u2212 mice. FLIP was found to be selectively overexpressed in the LNs of IL-2\u2212\/\u2212 mice, but no overexpression was found in spleen cells or thymocytes. These results suggest that FLIP, in conjunction with other IL-2-regulated genes previously characterized in our laboratory, is involved in controlling lymphoadenopathy in IL-2\u2212\/\u2212 mice.<\/jats:p>","DOI":"10.4049\/jimmunol.169.7.3644","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:18:01Z","timestamp":1398107881000},"page":"3644-3651","source":"Crossref","is-referenced-by-count":6,"title":["Lymphoadenopathy in IL-2-Deficient Mice: Further Characterization and Overexpression of the Antiapoptotic Molecule Cellular FLIP"],"prefix":"10.1093","volume":"169","author":[{"given":"Patricia","family":"Chastagner","sequence":"first","affiliation":[{"name":"Unite\u0301 d\u2019Immunoge\u0301ne\u0301tique Cellulaire, De\u0301partement de Me\u0301decine Mole\u0301culaire, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Reddy","sequence":"additional","affiliation":[{"name":"Unite\u0301 d\u2019Immunoge\u0301ne\u0301tique Cellulaire, De\u0301partement de Me\u0301decine Mole\u0301culaire, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"The\u0300ze","sequence":"additional","affiliation":[{"name":"Unite\u0301 d\u2019Immunoge\u0301ne\u0301tique Cellulaire, De\u0301partement de Me\u0301decine Mole\u0301culaire, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"2026020209243878100_R1","first-page":"1169","volume-title":"Science","year":"1988"},{"key":"2026020209243878100_R2","first-page":"481","volume-title":"Immunol. 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