{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:21:34Z","timestamp":1789845694270,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To determine the possible role of polymerase \u03b7 (pol \u03b7) in somatic hypermutation of B cells, a mutational analysis of 24 nonproductive rearrangements from a patient with xeroderma pigmentosum variant with a defect in pol \u03b7 was conducted. Although the mutational frequency of A and T bases decreased in WA (A\/T, A) motifs, regardless of their RGYW (purine, G; pyrimidine, A\/T) context, the overall mutational frequency of A or T bases was not affected. Moreover, the overall mutational frequency of the sequences examined was not decreased. There was an apparent increase in the number of insertions and deletions. The results are consistent with the conclusion that pol \u03b7 specifically targets WA motifs. However, its overall contribution to the somatic hypermutational process does not appear to be indispensable and in its absence other mechanisms maintain mutational activity.<\/jats:p>","DOI":"10.4049\/jimmunol.169.7.3825","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:18:01Z","timestamp":1398107881000},"page":"3825-3830","source":"Crossref","is-referenced-by-count":32,"title":["The Role of Polymerase \u03b7 in Somatic Hypermutation Determined by Analysis of Mutations in a Patient with Xeroderma Pigmentosum Variant"],"prefix":"10.1093","volume":"169","author":[{"given":"Sule","family":"Yavuz","sequence":"first","affiliation":[{"name":"Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akif S","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Basic Research Laboratory, National Cancer Institute , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E","family":"Lipsky","sequence":"additional","affiliation":[{"name":"Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"2026020209223108700_R1","first-page":"208","volume-title":"Curr. Opin. Immunol.","year":"2001"},{"key":"2026020209223108700_R2","first-page":"2779","volume-title":"J. Immunol.","year":"1997"},{"key":"2026020209223108700_R3","first-page":"522","volume-title":"Immunol. Today","year":"1999"},{"key":"2026020209223108700_R4","first-page":"1745","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020209223108700_R5","first-page":"135","volume-title":"Immunity","year":"1998"},{"key":"2026020209223108700_R6","first-page":"767","volume-title":"Int. Immunol.","year":"2000"},{"key":"2026020209223108700_R7","first-page":"553","volume-title":"Cell","year":"2000"},{"key":"2026020209223108700_R8","first-page":"589","volume-title":"Immunity","year":"2000"},{"key":"2026020209223108700_R9","first-page":"216","volume-title":"Nature","year":"2000"},{"key":"2026020209223108700_R10","first-page":"33","volume-title":"Clin. Dermatol.","year":"1985"},{"key":"2026020209223108700_R11","first-page":"86","volume-title":"Mol. Med. Today","year":"1999"},{"key":"2026020209223108700_R12","first-page":"700","volume-title":"Nature","year":"1999"},{"key":"2026020209223108700_R13","first-page":"263","volume-title":"Science","year":"1999"},{"key":"2026020209223108700_R14","first-page":"3094","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020209223108700_R15","first-page":"7447","volume-title":"J. Biol. Chem.","year":"2000"},{"key":"2026020209223108700_R16","first-page":"3100","volume-title":"EMBO J.","year":"2000"},{"key":"2026020209223108700_R17","first-page":"1011","volume-title":"Nature","year":"2000"},{"key":"2026020209223108700_R18","first-page":"537","volume-title":"Nat. Immunol.","year":"2001"},{"key":"2026020209223108700_R19","first-page":"530","volume-title":"Nat. Immunol.","year":"2001"},{"key":"2026020209223108700_R20","first-page":"982","volume-title":"Nat. Immunol.","year":"2001"},{"key":"2026020209223108700_R21","first-page":"2137","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020209223108700_R22","first-page":"19","volume-title":"Mol. Immunol.","year":"2001"},{"key":"2026020209223108700_R23","first-page":"3384","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026020209223108700_R24","first-page":"643","volume-title":"Immunity","year":"2001"},{"key":"2026020209223108700_R25","first-page":"7976","volume-title":"Proc. Natl. Acad. Sci USA","year":"2001"},{"key":"2026020209223108700_R26","first-page":"9","volume-title":"Cell","year":"2001"},{"key":"2026020209223108700_R27","first-page":"7995","volume-title":"Mol. Cell. Biol.","year":"2001"},{"key":"2026020209223108700_R28","first-page":"3702","volume-title":"J. Immunol.","year":"2002"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/169\/7\/3825\/62561481\/3825.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/169\/7\/3825\/62561481\/3825.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:31:39Z","timestamp":1770042699000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/169\/7\/3825\/8027582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,1]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2002,10,1]]},"published-print":{"date-parts":[[2002,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.169.7.3825","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,10]]},"published":{"date-parts":[[2002,10,1]]}}}