{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:16:21Z","timestamp":1790867781616,"version":"4.1.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Impaired development of local Ab responses may predispose HIV-1-infected patients to an increased rate, severity, and duration of mucosal infections. We characterized the repertoire of Ig-producing cells in the intestinal effector compartment (the lamina propria) of HIV-1-infected (n = 29) and seronegative control (n = 27) subjects. The density of Ig-producing cells per area was similar in both groups. However, the proportions of IgA-producing cells were lower in both the duodenum and colon from HIV-1-infected patients compared with those of control subjects (p &amp;lt; 0.05), with compensatory increases in IgG-producing cells in the colon and IgM-producing cells in the duodenum. Similarly, among Abs in the lumen the proportions of IgA were also decreased and the proportions of IgG were increased among HIV-1-infected patients. On a molecular level, VH gene repertoire analyses by RT-PCR revealed comparable proportions of the VH3 family among duodenal IgA transcripts (50\u201353%) from both groups. VH3 expression was decreased only for IgM among patients with advanced HIV-1 disease (n = 6) compared with that of control subjects (n = 8) (48 \u00b1 8 vs 62 \u00b1 13%; p &amp;lt; 0.01). Moreover, the frequencies of individual IgM and IgA VH3 genes were comparable in each group, including rates of putative HIV-1 gp120-binding VH3 genes (V3-23, V3-30, V3-30\/3-30.5). We conclude that, despite a decrement in local IgA producing cells, the density and molecular VH repertoire of mucosal plasma cells are relatively intact among patients with HIV-1 infection. These data suggest that HIV-1-infected patients use functional regulatory mechanisms to provide sufficient VH diversity and effective induction and differentiation of mucosal B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.169.7.4008","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:18:01Z","timestamp":1398107881000},"page":"4008-4016","source":"Crossref","is-referenced-by-count":29,"title":["Mucosal Plasma Cell Repertoire During HIV-1 Infection"],"prefix":"10.1093","volume":"169","author":[{"given":"Ronald W","family":"Scamurra","sequence":"first","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Infectious Disease, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B","family":"Nelson","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Gastroenterology, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Mei","family":"Lin","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Infectious Disease, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren J","family":"Miller","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Infectious Disease, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg J","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California at San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Kappel","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Laboratory Medicine and Pathology, Veteran Affairs Medical Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R","family":"Thurn","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Infectious Disease, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Infectious Disease, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Kulkarni-Narla","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Infectious Disease, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward N","family":"Janoff","sequence":"additional","affiliation":[{"name":"Mucosal and Vaccine Research Center, University of Minnesota School of Medicine , Minneapolis, MN 55417"},{"name":"Section of Infectious Disease, University of Minnesota School of Medicine , Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"2026020209210455800_R1","first-page":"63","volume-title":"Ann. 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