{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:49:03Z","timestamp":1792482543696,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Large mammalian proteins containing a nucleotide-binding domain (NBD) and C-terminal leucine-rich repeats (LRR) similar in structure to plant disease resistance proteins have been suggested as critical in innate immunity. Our interest in CIITA, a NBD\/LRR protein, and recent reports linking mutations in two other NBD\/LRR proteins to inflammatory disorders have prompted us to perform a search for other members. Twenty-two known and novel NBD\/LRR genes are spread across eight human chromosomes, with multigene clusters occurring on 11, 16, and 19. Most of these are telomeric. Their N termini vary, but most have a pyrin domain. The genomic organization demonstrates a high degree of conservation of the NBD- and LRR-encoding exons. Except for CIITA, all the predicted NBD\/LRR proteins are likely ATP-binding proteins. Some have broad tissue expression, whereas others are restricted to myeloid cells. The implications of these data on origins, expression, and function of these genes are discussed.<\/jats:p>","DOI":"10.4049\/jimmunol.169.8.4088","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:03:53Z","timestamp":1398024233000},"page":"4088-4093","source":"Crossref","is-referenced-by-count":265,"title":["Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains"],"prefix":"10.1093","volume":"169","author":[{"given":"Jonathan A","family":"Harton","sequence":"first","affiliation":[{"name":"Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W","family":"Linhoff","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny P-Y","family":"Ting","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,10,15]]},"reference":[{"key":"2026020210031222500_R1","first-page":"135","volume-title":"Cell","year":"1993"},{"key":"2026020210031222500_R2","first-page":"603","volume-title":"Nature","year":"2001"},{"key":"2026020210031222500_R3","first-page":"599","volume-title":"Nature","year":"2001"},{"key":"2026020210031222500_R4","first-page":"301","volume-title":"Nat. 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