{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:18:30Z","timestamp":1791310710544,"version":"4.3.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>BLyS and APRIL are two members of the TNF superfamily that are secreted by activated myeloid cells and have costimulatory activity on B cells. BLyS and APRIL share two receptors, TACI and BCMA, whereas a third receptor, BAFF-R, specifically binds BLyS. Both BLyS and APRIL have been described as homotrimeric molecules, a feature common to members of the TNF superfamily. In this study, we show that APRIL and BLyS can form active heterotrimeric molecules when coexpressed and that circulating heterotrimers are present in serum samples from patients with systemic immune-based rheumatic diseases. These findings raise the possibility that active BLyS\/APRIL heterotrimers may play a role in rheumatic and other autoimmune diseases and that other members of the TNF ligand superfamily may also form active soluble heterotrimers.<\/jats:p>","DOI":"10.4049\/jimmunol.169.8.4314","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:03:53Z","timestamp":1398024233000},"page":"4314-4321","source":"Crossref","is-referenced-by-count":226,"title":["BLyS and APRIL Form Biologically Active Heterotrimers That Are Expressed in Patients with Systemic Immune-Based Rheumatic Diseases"],"prefix":"10.1093","volume":"169","author":[{"given":"Viktor","family":"Roschke","sequence":"first","affiliation":[{"name":"Department of Antibody Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Sosnovtseva","sequence":"additional","affiliation":[{"name":"Department of Antibody Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Preclinical Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June S","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Preclinical Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodger","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Antibody Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Antibody Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Stohl","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Los Angeles County and University of Southern California Medical Center and Keck School of Medicine, University of Southern California , Los Angeles, CA, 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Preclinical Discovery, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Protein Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardetta","family":"Nardelli","sequence":"additional","affiliation":[{"name":"Department of Preclinical Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Hilbert","sequence":"additional","affiliation":[{"name":"Department of Preclinical Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi-Sau","family":"Migone","sequence":"additional","affiliation":[{"name":"Department of Preclinical Development, Human Genome Sciences , Rockville, MD, 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,10,15]]},"reference":[{"key":"2026020209214391500_R1","first-page":"487","volume-title":"Cell","year":"2002"},{"key":"2026020209214391500_R2","first-page":"260","volume-title":"Science","year":"1999"},{"key":"2026020209214391500_R3","first-page":"15978","volume-title":"J. Biol. Chem.","year":"1999"},{"key":"2026020209214391500_R4","first-page":"1747","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020209214391500_R5","first-page":"785","volume-title":"Curr. Biol.","year":"2000"},{"key":"2026020209214391500_R6","first-page":"995","volume-title":"Nature","year":"2000"},{"key":"2026020209214391500_R7","first-page":"129","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020209214391500_R8","first-page":"156","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020209214391500_R9","first-page":"252","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2026020209214391500_R10","first-page":"35478","volume-title":"J. Biol. Chem.","year":"2000"},{"key":"2026020209214391500_R11","first-page":"2108","volume-title":"Science","year":"2001"},{"key":"2026020209214391500_R12","first-page":"2111","volume-title":"Science","year":"2001"},{"key":"2026020209214391500_R13","first-page":"289","volume-title":"Immunity","year":"2001"},{"key":"2026020209214391500_R14","first-page":"1313","volume-title":"Arthritis Rheum.","year":"2001"},{"key":"2026020209214391500_R15","first-page":"6","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020209214391500_R16","first-page":"59","volume-title":"J. Clin. Invest.","year":"2002"},{"key":"2026020209214391500_R17","first-page":"1185","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020209214391500_R18","first-page":"1021","volume-title":"Cancer Res.","year":"2000"},{"key":"2026020209214391500_R19","first-page":"2351","volume-title":"Science","year":"2000"},{"key":"2026020209214391500_R20","first-page":"383","volume-title":"Cell","year":"2002"},{"key":"2026020209214391500_R21","first-page":"25","volume-title":"Cytokine","year":"2001"},{"key":"2026020209214391500_R22","first-page":"847","volume-title":"Cell","year":"1993"},{"key":"2026020209214391500_R23","first-page":"707","volume-title":"Science","year":"1994"},{"key":"2026020209214391500_R24","first-page":"19451","volume-title":"J. Biol. Chem.","year":"1997"},{"key":"2026020209214391500_R25","first-page":"231","volume-title":"Somatic Cell Genet.","year":"1977"},{"key":"2026020209214391500_R26","first-page":"147","volume-title":"J. Immunol. Methods","year":"1983"},{"key":"2026020209214391500_R27","first-page":"309","volume-title":"Nat. Biotechnol.","year":"1996"},{"key":"2026020209214391500_R28","first-page":"581","volume-title":"J. Mol. Biol.","year":"1991"},{"key":"2026020209214391500_R29","first-page":"9","volume-title":"Gene","year":"1997"},{"key":"2026020209214391500_R30","volume-title":"Primer on the Rheumatic Diseases","year":"2001"},{"key":"2026020209214391500_R31","first-page":"F35","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020209214391500_R32","first-page":"2012","volume-title":"Science","year":"2001"},{"key":"2026020209214391500_R33","first-page":"485","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020209214391500_R34","first-page":"5993","volume-title":"J. Immunol.","year":"2002"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/169\/8\/4314\/62561717\/4314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/169\/8\/4314\/62561717\/4314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:30:30Z","timestamp":1770042630000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/169\/8\/4314\/8027489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":34,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2002,10,15]]},"published-print":{"date-parts":[[2002,10,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.169.8.4314","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,10]]},"published":{"date-parts":[[2002,10]]}}}