{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:13:11Z","timestamp":1771632791732,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>C57BL\/6 mice deficient in E- and P-selectin (E\u2212\/\u2212P\u2212\/\u2212) kept under specific pathogen-free barrier conditions have high circulating neutrophil counts and develop hypercellular cervical lymph nodes with substantial plasma cell infiltrates, severe ulcerative dermatitis, conjunctivitis, and lung pathology, which eventually lead to premature death. To test the hypothesis that the pathology in E\u2212\/\u2212P\u2212\/\u2212 mice may be caused by dysfunctional lymphocyte activity, we crossed E\u2212\/\u2212P\u2212\/\u2212 mice with recombination activation gene (Rag)-1\u2212\/\u2212 mice to generate E\u2212\/\u2212P\u2212\/\u2212Rag-1\u2212\/\u2212 mice lacking mature T and B lymphocytes. E\u2212\/\u2212P\u2212\/\u2212Rag-1\u2212\/\u2212 mice had circulating neutrophil counts and plasma G-CSF levels similar to E\u2212\/\u2212P\u2212\/\u2212 mice. Remarkably, none of the E\u2212\/\u2212P\u2212\/\u2212Rag-1\u2212\/\u2212 mice developed conjunctivitis or ulcerative dermatitis typical of E\u2212\/\u2212P\u2212\/\u2212 mice. These mice were overall healthier in appearance than E\u2212\/\u2212P\u2212\/\u2212 mice, and histopathologic changes in the lung were reduced. Cervical lymph nodes in E\u2212\/\u2212P\u2212\/\u2212Rag-1\u2212\/\u2212 mice were much smaller than those of E\u2212\/\u2212P\u2212\/\u2212 mice, containing few mononuclear cells and no plasma cells. These data show that the severe disease phenotype of E\u2212\/\u2212P\u2212\/\u2212 mice depends on lymphocyte function. We conclude that a dysregulated immune response in E\u2212\/\u2212P\u2212\/\u2212 mice causes disease development, but is not necessary for elevated neutrophil counts.<\/jats:p>","DOI":"10.4049\/jimmunol.169.9.4797","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:57:06Z","timestamp":1398027426000},"page":"4797-4804","source":"Crossref","is-referenced-by-count":10,"title":["T Cell Requirement for Development of Chronic Ulcerative Dermatitis in E- and P-Selectin-Deficient Mice"],"prefix":"10.1093","volume":"169","author":[{"given":"S Bradley","family":"Forlow","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Virginia , Charlottesville, VA 22908"},{"name":"Cardiovascular Research Center, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E James","family":"White","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennard L","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Virginia , Charlottesville, VA 22908"},{"name":"Center for Blood Research, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J","family":"Bagby","sequence":"additional","affiliation":[{"name":"Department of Physiology, Louisiana State University Health Sciences Center , New Orleans, LA 70112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L","family":"Foley","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Ley","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Virginia , Charlottesville, VA 22908"},{"name":"Cardiovascular Research Center, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"2026020210022525400_R1","first-page":"2329","volume-title":"J. 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