{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:39:45Z","timestamp":1791160785003,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IFN-\u03ba is a recently identified type I IFN that exhibits both structural and functional homology with the other type I IFN subclasses. In this study, we have investigated the effect of IFN-\u03ba on cells of the innate immune system by comparing cytokine release following treatment of human cells with either IFN-\u03ba or two recombinant IFN subtypes, IFN-\u03b2 and IFN-\u03b12a. Although IFN-\u03b12a failed to stimulate monocyte cytokine secretion, IFN-\u03ba, like IFN-\u03b2, induced the release of several cytokines from both monocytes and dendritic cells, without the requirement of a costimulatory signal. IFN-\u03ba was particularly effective in inhibiting inducible IL-12 release from monocytes. Unlike IFN-\u03b2, IFN-\u03ba did not induce release of IFN-\u03b3 by PBL. Expression of the IFN-\u03ba mRNA was observed in resting dendritic cells and monocytes, and it was up-regulated by IFN-\u03b3 stimulation in monocytes, while IFN-\u03b2 mRNA was minimally detectable under the same conditions. Monocyte and dendritic cell expression of IFN-\u03ba was also confirmed in vivo in chronic lesions of psoriasis vulgaris and atopic dermatitis. Finally, biosensor-based binding kinetic analysis revealed that IFN-\u03ba, like IFN-\u03b2, binds strongly to heparin (Kd: 2.1 nM), suggesting that the cytokine can be retained close to the local site of production. The pattern of cytokines induced by IFN-\u03ba in monocytes, coupled with the unique induction of IFN-\u03ba mRNA by IFN-\u03b3, indicates a potential role for IFN-\u03ba in the regulation of immune cell functions.<\/jats:p>","DOI":"10.4049\/jimmunol.169.9.4822","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:57:06Z","timestamp":1398041826000},"page":"4822-4830","source":"Crossref","is-referenced-by-count":81,"title":["Regulatory Effect of IFN-\u03ba, A Novel Type I IFN, On Cytokine Production by Cells of the Innate Immune System"],"prefix":"10.1093","volume":"169","author":[{"given":"Bernardetta","family":"Nardelli","sequence":"first","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov","family":"Zaritskaya","sequence":"additional","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Semenuk","sequence":"additional","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"LaFleur","sequence":"additional","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanshi","family":"Shah","sequence":"additional","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Albanesi","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell\u2019Immacolata , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Moore","sequence":"additional","affiliation":[{"name":"Human Genome Sciences , Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"2025032711391941000_R1","first-page":"805","volume-title":"J. 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