{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:01:19Z","timestamp":1771653679637,"version":"3.50.1"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD8+ T cells respond to IL-2 produced both endogenously and by CD4+ Th during an antiviral response. However, IL-2R signals can potentially promote CD8+ T cell death as well as proliferation, making it unclear whether IL-2R signals provide a predominantly positive or negative effect upon CD8+ T cell responses to viral infection. To more precisely define the direct role of IL-2R signaling on CD8+ T cells during the response to a virus, we examined the effect of delivering augmented IL-2R signals selectively to CD8+ T cells responding to lymphocytic choriomeningitis virus infection. Although naive CD8+ T cells are competent to produce IL-2, CD8+ T cells lose this capacity upon differentiation into effector CD8+ T cells. However, effector CD8+ T cells do retain the capacity to produce GM-CSF upon Ag stimulation. Thus, to deliver enhanced autocrine IL-2R signals to CD8+ T cells, we established a transgenic mouse strain expressing a chimeric GM-CSF\/IL-2R (GMIL2R). As GM-CSF production is Ag dependent, the GMIL2R delivers an augmented IL-2R signal exclusively to CD8+ T cells responding to Ag. Following lymphocytic choriomeningitis virus infection, GMIL2R transgenic mice exhibited an increase in both the peak CD8+ T cell response achieved and the size of the resulting memory pool established. Upon secondary viral challenge, the GMIL2R also enhanced the proliferative response of memory CD8+ T cells. Thus, our findings indicate that IL-2 delivery to responding CD8+ T cells is a limiting factor in both the acute and memory antiviral responses.<\/jats:p>","DOI":"10.4049\/jimmunol.169.9.4990","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:57:06Z","timestamp":1398027426000},"page":"4990-4997","source":"Crossref","is-referenced-by-count":28,"title":["Selective Delivery of Augmented IL-2 Receptor Signals to Responding CD8+ T Cells Increases the Size of the Acute Antiviral Response and of the Resulting Memory T Cell Pool"],"prefix":"10.1093","volume":"169","author":[{"given":"Laurence E","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"},{"name":"Program in Immunology, Fred Hutchinson Cancer Research Center , Seattle, WA 98109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip D","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, WA 98195"},{"name":"Department of Oncology, University of Washington , Seattle, WA 98195"},{"name":"Program in Immunology, Fred Hutchinson Cancer Research Center , Seattle, WA 98109"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"2026020209223075000_R1","first-page":"54","volume-title":"Science","year":"1996"},{"key":"2026020209223075000_R2","first-page":"1072","volume-title":"J. Virol.","year":"1996"},{"key":"2026020209223075000_R3","first-page":"9293","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1999"},{"key":"2026020209223075000_R4","first-page":"1373","volume-title":"Blood","year":"1991"},{"key":"2026020209223075000_R5","first-page":"1971","volume-title":"Blood","year":"1994"},{"key":"2026020209223075000_R6","first-page":"1038","volume-title":"N. Engl. J. Med.","year":"1995"},{"key":"2026020209223075000_R7","first-page":"405","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026020209223075000_R8","first-page":"474","volume-title":"Nature","year":"1998"},{"key":"2026020209223075000_R9","first-page":"478","volume-title":"Nature","year":"1998"},{"key":"2026020209223075000_R10","first-page":"480","volume-title":"Nature","year":"1998"},{"key":"2026020209223075000_R11","first-page":"1875","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020209223075000_R12","first-page":"2129","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020209223075000_R13","first-page":"1","volume-title":"Adv. Immunol.","year":"1998"},{"key":"2026020209223075000_R14","first-page":"507","volume-title":"J. Leukocyte Biol.","year":"1997"},{"key":"2026020209223075000_R15","first-page":"1190","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020209223075000_R16","first-page":"154","volume-title":"Nature","year":"1977"},{"key":"2026020209223075000_R17","first-page":"1210","volume-title":"J. Immunol.","year":"1989"},{"key":"2026020209223075000_R18","first-page":"221","volume-title":"Annu. Rev. Immunol.","year":"1999"},{"key":"2026020209223075000_R19","first-page":"621","volume-title":"Nature","year":"1991"},{"key":"2026020209223075000_R20","first-page":"4842","volume-title":"J. Virol.","year":"1995"},{"key":"2026020209223075000_R21","first-page":"5690","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020209223075000_R22","first-page":"253","volume-title":"Cell","year":"1993"},{"key":"2026020209223075000_R23","first-page":"675","volume-title":"Science","year":"2000"},{"key":"2026020209223075000_R24","first-page":"5945","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020209223075000_R25","first-page":"371","volume-title":"Int. Immunol.","year":"1998"},{"key":"2026020209223075000_R26","first-page":"1137","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020209223075000_R27","first-page":"8832","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026020209223075000_R28","first-page":"537","volume-title":"Immunity","year":"1997"},{"key":"2026020209223075000_R29","first-page":"3001","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026020209223075000_R30","first-page":"4295","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1992"},{"key":"2026020209223075000_R31","first-page":"2472","volume-title":"Eur. J. Immunol.","year":"1993"},{"key":"2026020209223075000_R32","first-page":"3748","volume-title":"Blood","year":"1999"},{"key":"2026020209223075000_R33","first-page":"333","volume-title":"Nature","year":"1994"},{"key":"2026020209223075000_R34","first-page":"309","volume-title":"Mol. Cell. Biol.","year":"1996"},{"key":"2026020209223075000_R35","first-page":"1878","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1997"},{"key":"2026020209223075000_R36","first-page":"51","volume-title":"Immunol. Cell Biol.","year":"1992"},{"key":"2026020209223075000_R37","first-page":"486","volume-title":"Science","year":"2000"},{"key":"2026020209223075000_R38","first-page":"114","volume-title":"Nat. Med.","year":"2001"},{"key":"2026020209223075000_R39","first-page":"243","volume-title":"Science","year":"1998"},{"key":"2026020209223075000_R40","first-page":"5754","volume-title":"J. Virol.","year":"1993"},{"key":"2026020209223075000_R41","first-page":"758","volume-title":"Nature","year":"1993"},{"key":"2026020209223075000_R42","first-page":"8056","volume-title":"J. Virol.","year":"1994"},{"key":"2026020209223075000_R43","first-page":"2413","volume-title":"Science","year":"2001"},{"key":"2026020209223075000_R44","first-page":"2102","volume-title":"J. Virol.","year":"1988"},{"key":"2026020209223075000_R45","first-page":"177","volume-title":"Immunity","year":"1998"},{"key":"2026020209223075000_R46","first-page":"113","volume-title":"Annu. Rev. Cell. Dev. Biol.","year":"1999"},{"key":"2026020209223075000_R47","first-page":"1","volume-title":"Exp. Hematol.","year":"1987"},{"key":"2026020209223075000_R48","first-page":"1131","volume-title":"Blood","year":"1991"},{"key":"2026020209223075000_R49","first-page":"2602","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020209223075000_R50","first-page":"1377","volume-title":"Science","year":"1999"},{"key":"2026020209223075000_R51","first-page":"559","volume-title":"Nature","year":"1989"},{"key":"2026020209223075000_R52","first-page":"708","volume-title":"Nature","year":"1999"},{"key":"2026020209223075000_R53","first-page":"101","volume-title":"Nature","year":"2001"},{"key":"2026020209223075000_R54","first-page":"6874","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1997"},{"key":"2026020209223075000_R55","first-page":"5565","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020209223075000_R56","first-page":"913","volume-title":"Nat. Med.","year":"2001"},{"key":"2026020209223075000_R57","first-page":"2533","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020209223075000_R58","first-page":"5566","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020209223075000_R59","first-page":"3053","volume-title":"Eur. J. Immunol.","year":"1995"},{"key":"2026020209223075000_R60","first-page":"3131","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020209223075000_R61","first-page":"11445","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020209223075000_R62","first-page":"1552","volume-title":"Eur. J. Immunol.","year":"1993"},{"key":"2026020209223075000_R63","first-page":"1575","volume-title":"FASEB J.","year":"1999"},{"key":"2026020209223075000_R64","first-page":"6292","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020209223075000_R65","first-page":"5153","volume-title":"Oncogene","year":"2000"},{"key":"2026020209223075000_R66","first-page":"753","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020209223075000_R67","first-page":"297","volume-title":"J. Leukocyte Biol.","year":"2002"},{"key":"2026020209223075000_R68","first-page":"4827","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020209223075000_R69","first-page":"1138","volume-title":"Nat. Immun.","year":"2001"},{"key":"2026020209223075000_R70","first-page":"1683","volume-title":"N. Engl. J. Med.","year":"1999"},{"key":"2026020209223075000_R71","first-page":"R13","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2026020209223075000_R72","first-page":"881","volume-title":"Nat. Med.","year":"2001"},{"key":"2026020209223075000_R73","first-page":"3399","volume-title":"J. Clin. Oncol.","year":"1997"},{"key":"2026020209223075000_R74","first-page":"3957","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1999"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/169\/9\/4990\/62558776\/4990.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/169\/9\/4990\/62558776\/4990.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:31:38Z","timestamp":1770042698000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/169\/9\/4990\/8027581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,1]]},"references-count":74,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2002,11,1]]},"published-print":{"date-parts":[[2002,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.169.9.4990","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,11]]},"published":{"date-parts":[[2002,11,1]]}}}