{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:07:00Z","timestamp":1791194820013,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-2 and IL-15 are thought to be important cytokines for T cell-dependent immune responses. Mice deficient in IL-2, IL-2R\u03b1, and IL-2R\u03b2 are each characterized by a rapid lethal autoimmune lymphoproliferative disorder that complicates their use in studies aimed at investigating the role of these cytokines and receptors for immune responses in vivo. We have previously characterized a novel transgenic (Tg) mouse on the IL-2R\u03b2\u2212\/\u2212 genetic background (Tg\u2212\/\u2212 mice) that lacks autoimmune disease but still contains peripheral T cells that are nonresponsive to IL-2 and IL-15. In the present study, these mice were used to investigate the extent by which IL-2 and IL-15 are essential for T cell immunity in vivo. Tg\u2212\/\u2212 mice generated near normal primary and secondary Ab responses to OVA, readily mounted first and second set allogeneic skin graft rejection responses, and developed primary and recall CD8 T cell responses to vaccinia virus. However, Tg\u2212\/\u2212 mice generated a slightly lower level of IgG2a Abs to OVA, exhibited a somewhat delayed first set skin graft rejection response with lower allo-specific CTL, and developed a significantly lower number of IFN-\u03b3-producing vaccinia-specific CD8+ T cells. Thus, although T effector function is somewhat impaired, T cell immunity is largely functional in the absence of IL-2- and IL-15-induced signaling through IL-2R\u03b2.<\/jats:p>","DOI":"10.4049\/jimmunol.170.1.236","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:11:17Z","timestamp":1398125477000},"page":"236-242","source":"Crossref","is-referenced-by-count":42,"title":["Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors"],"prefix":"10.1093","volume":"170","author":[{"given":"Aixin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami School of Medicine , Miami, FL 33101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Marten","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia C","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Southern California , Los Angeles, CA 90033"},{"name":"Department of Neurology, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Mammolenti","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami School of Medicine , Miami, FL 33101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami School of Medicine , Miami, FL 33101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Malek","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami School of Medicine , Miami, FL 33101"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"2026020210112331600_R1","first-page":"503","volume-title":"Crit. 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Immunol.","year":"2002"},{"key":"2026020210112331600_R22","first-page":"1541","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020210112331600_R23","first-page":"2905","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020210112331600_R24","first-page":"1675","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210112331600_R25","first-page":"167","volume-title":"Immunity","year":"2002"},{"key":"2026020210112331600_R26","first-page":"315","volume-title":"J. Gen. Virol.","year":"1996"},{"key":"2026020210112331600_R27","first-page":"2679","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1992"},{"key":"2026020210112331600_R28","first-page":"3905","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210112331600_R29","first-page":"8127","volume-title":"J. Virol.","year":"1995"},{"key":"2026020210112331600_R30","first-page":"3379","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210112331600_R31","first-page":"3373","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2026020210112331600_R32","first-page":"4114","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020210112331600_R33","first-page":"335","volume-title":"Transplantation","year":"1997"},{"key":"2026020210112331600_R34","first-page":"156","volume-title":"Eur. J. Immunol.","year":"1999"},{"key":"2026020210112331600_R35","first-page":"1226","volume-title":"Infect. Immun.","year":"2001"},{"key":"2026020210112331600_R36","first-page":"147","volume-title":"Cell","year":"1993"},{"key":"2026020210112331600_R37","first-page":"591","volume-title":"Immunity","year":"1998"},{"key":"2026020210112331600_R38","first-page":"675","volume-title":"Science","year":"2000"},{"key":"2026020210112331600_R39","first-page":"871","volume-title":"J. Clin. Invest.","year":"2001"},{"key":"2026020210112331600_R40","first-page":"1515","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020210112331600_R41","first-page":"1523","volume-title":"J. Exp. 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