{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:35:37Z","timestamp":1791221737287,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adapter proteins play a critical role in regulating signals triggered by Ag receptor cross-linking. These small molecules link receptor proximal events with downstream signaling pathways. In this study, we explore the expression and function of the Grb2-related protein of the lymphoid system (GrpL)\/Grb2-related adaptor downstream of Shc adapter protein in human B cells. GrpL is expressed in naive B cells and is down-regulated following B cell Ag receptor ligation. By contrast, germinal center and memory B cells express little or no GrpL. Using human B cell lines, we detected constitutive interactions between GrpL and B cell linker protein, Src homology (SH)2 domain-containing leukocyte protein of 76 kDa, hemopoietic progenitor kinase 1, and c-Cbl. The N-terminal SH3 domain of GrpL binds c-Cbl while the C-terminal SH3 domain binds B cell linker protein and SH2 domain-containing leukocyte protein of 76 kDa. Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced Ag receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase phosphorylation. Thus, GrpL expression in human B cell subsets appears to regulate Ag receptor-mediated signaling events.<\/jats:p>","DOI":"10.4049\/jimmunol.170.1.349","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T04:11:17Z","timestamp":1398139877000},"page":"349-355","source":"Crossref","is-referenced-by-count":10,"title":["Expression of the Grb2-Related Protein of the Lymphoid System in B Cell Subsets Enhances B Cell Antigen Receptor Signaling Through Mitogen-Activated Protein Kinase Pathways"],"prefix":"10.1093","volume":"170","author":[{"given":"Thomas M","family":"Yankee","sequence":"first","affiliation":[{"name":"Microbiology, University of Washington , Seattle WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha A","family":"Solow","sequence":"additional","affiliation":[{"name":"Microbiology, University of Washington , Seattle WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D","family":"Draves","sequence":"additional","affiliation":[{"name":"Microbiology, University of Washington , Seattle WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A","family":"Clark","sequence":"additional","affiliation":[{"name":"Microbiology, University of Washington , Seattle WA 98195"},{"name":"Immunology, University of Washington , Seattle WA 98195"},{"name":"National Primate Research Center, University of Washington , Seattle WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"2025032709195725300_R1","first-page":"185","volume-title":"Rev. Immunogenet.","year":"2000"},{"key":"2025032709195725300_R2","first-page":"30","volume-title":"Immunol. Rev.","year":"2000"},{"key":"2025032709195725300_R3","first-page":"241","volume-title":"Curr. Opin. Immunol.","year":"2002"},{"key":"2025032709195725300_R4","first-page":"2101","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032709195725300_R5","first-page":"1073","volume-title":"Cell","year":"1997"},{"key":"2025032709195725300_R6","first-page":"389","volume-title":"Nature","year":"1994"},{"key":"2025032709195725300_R7","first-page":"691","volume-title":"Immunity","year":"1995"},{"key":"2025032709195725300_R8","first-page":"2313","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032709195725300_R9","first-page":"123","volume-title":"Adv. Immunol.","year":"2001"},{"key":"2025032709195725300_R10","first-page":"1243","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2025032709195725300_R11","first-page":"3073","volume-title":"Oncogene","year":"1998"},{"key":"2025032709195725300_R12","first-page":"7273","volume-title":"EMBO J.","year":"1998"},{"key":"2025032709195725300_R13","first-page":"1383","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2025032709195725300_R14","first-page":"5805","volume-title":"J. Immunol.","year":"2000"},{"key":"2025032709195725300_R15","first-page":"67","volume-title":"Curr. Biol.","year":"1999"},{"key":"2025032709195725300_R16","first-page":"1987","volume-title":"Science","year":"2001"},{"key":"2025032709195725300_R17","first-page":"5786","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032709195725300_R18","first-page":"6789","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2025032709195725300_R19","first-page":"359","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1995"},{"key":"2025032709195725300_R20","first-page":"239","volume-title":"Immunity","year":"1995"},{"key":"2025032709195725300_R21","first-page":"1319","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2025032709195725300_R22","first-page":"6829","volume-title":"Mol. Cell. Biol.","year":"1995"},{"key":"2025032709195725300_R23","first-page":"12144","volume-title":"J. Biol. Chem.","year":"2002"},{"key":"2025032709195725300_R24","first-page":"41040","volume-title":"J. Biol. Chem.","year":"2001"},{"key":"2025032709195725300_R25","first-page":"2075","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032709195725300_R26","first-page":"1006","volume-title":"J. Immunol.","year":"1996"},{"key":"2025032709195725300_R27","first-page":"143","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2025032709195725300_R28","first-page":"777","volume-title":"Int. Immunol.","year":"2001"},{"key":"2025032709195725300_R29","first-page":"113","volume-title":"FEBS Lett.","year":"2000"},{"key":"2025032709195725300_R30","first-page":"1287","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032709195725300_R31","first-page":"44315","volume-title":"J. Biol. Chem.","year":"2001"},{"key":"2025032709195725300_R32","first-page":"1009","volume-title":"Curr. Biol.","year":"1998"},{"key":"2025032709195725300_R33","first-page":"2126","volume-title":"Eur. J. Immunol.","year":"2001"},{"key":"2025032709195725300_R34","first-page":"2524","volume-title":"Mol. Cell. Biol.","year":"2002"},{"key":"2025032709195725300_R35","first-page":"457","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032709195725300_R36","first-page":"7029","volume-title":"J. Biol. Chem.","year":"1995"},{"key":"2025032709195725300_R37","first-page":"1725","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2025032709195725300_R38","first-page":"70","volume-title":"J. Immunol.","year":"1997"},{"key":"2025032709195725300_R39","first-page":"32306","volume-title":"J. Biol. Chem.","year":"1996"},{"key":"2025032709195725300_R40","first-page":"8564","volume-title":"J. Biol. Chem.","year":"1996"},{"key":"2025032709195725300_R41","first-page":"5827","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032709195725300_R42","first-page":"641","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2025032709195725300_R43","first-page":"93","volume-title":"Immunity","year":"1998"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/1\/349\/62565663\/349.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/1\/349\/62565663\/349.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T11:37:31Z","timestamp":1743334651000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/170\/1\/349\/8028446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.170.1.349","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,1]]},"published":{"date-parts":[[2003,1,1]]}}}