{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:25:46Z","timestamp":1790047546888,"version":"4.0.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recently, a new class of human dendritic cell (DC) precursors has been described in the peripheral blood recognized by the mAb M-DC8. These cells represent \u223c1% of PBMC and acquire several characteristics of myeloid DC upon in vitro culture. In this report we show that M-DC8+ monocytes secrete in response to LPS &amp;gt;10 times the amount of TNF-\u03b1 as M-DC8\u2212 monocytes, but produce significantly less IL-10. Consistent with a role in inflammatory responses, we found that M-DC8+ cells localized in the T cell area of inflamed human tonsils and in the subepithelial dome region of Peyer\u2019s patches. In patients with active Crohn\u2019s disease, abundant M-DC8+ cells were detectable in inflamed ileal mucosa, which were entirely depleted after systemic steroid treatment. Our results indicate that M-DC8+ cells are cells of DC phenotype in inflamed mucosa-associated lymphoid tissue that may contribute to the high level of TNF-\u03b1 production in Crohn\u2019s disease. We infer that selective elimination of M-DC8+ cells in inflammatory diseases has therapeutic potential.<\/jats:p>","DOI":"10.4049\/jimmunol.170.10.5089","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:31:23Z","timestamp":1398022283000},"page":"5089-5094","source":"Crossref","is-referenced-by-count":73,"title":["A Subset of Human Dendritic Cells in the T Cell Area of Mucosa-Associated Lymphoid Tissue with a High Potential to Produce TNF-\u03b1"],"prefix":"10.1093","volume":"170","author":[{"given":"Annegret","family":"de Baey","sequence":"first","affiliation":[{"name":"Micromet AG , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Mende","sequence":"additional","affiliation":[{"name":"Micromet AG , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Baretton","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Technical University of Dresden , Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Greiner","sequence":"additional","affiliation":[{"name":"Institute for Pathology, University of Wurzburg , Wurzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang H","family":"Hartl","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A","family":"Baeuerle","sequence":"additional","affiliation":[{"name":"Micromet AG , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut M","family":"Diepolder","sequence":"additional","affiliation":[{"name":"Internal Medicine II, University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,5,15]]},"reference":[{"key":"2026020210063514200_R1","first-page":"4084","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026020210063514200_R2","first-page":"1646","volume-title":"Eur. J. Immunol.","year":"2001"},{"key":"2026020210063514200_R3","first-page":"753","volume-title":"Immunity","year":"1999"},{"key":"2026020210063514200_R4","first-page":"91","volume-title":"Int. Rev. Cytol.","year":"1996"},{"key":"2026020210063514200_R5","first-page":"109","volume-title":"Trends Biotechnol.","year":"1991"},{"key":"2026020210063514200_R6","first-page":"1109","volume-title":"J. Exp. Med.","year":"1994"},{"key":"2026020210063514200_R7","first-page":"2053","volume-title":"Eur. J. Immunol.","year":"1993"},{"key":"2026020210063514200_R8","first-page":"1142","volume-title":"J. Exp. Med.","year":"1973"},{"key":"2026020210063514200_R9","first-page":"182","volume-title":"Gastroenterology","year":"1998"},{"key":"2026020210063514200_R10","first-page":"3536","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020210063514200_R11","first-page":"289","volume-title":"Immunity","year":"2002"},{"key":"2026020210063514200_R12","first-page":"28","volume-title":"Immunol. Today","year":"1988"},{"key":"2026020210063514200_R13","first-page":"285","volume-title":"Am. J. Pathol.","year":"2001"},{"key":"2026020210063514200_R14","first-page":"1381","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020210063514200_R15","first-page":"237","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020210063514200_R16","first-page":"1325","volume-title":"Eur. J. Immunol.","year":"1997"},{"key":"2026020210063514200_R17","first-page":"43","volume-title":"Pulm. Pharmacol.","year":"1994"},{"key":"2026020210063514200_R18","first-page":"205","volume-title":"Clin. Immunol. Immunopathol.","year":"1993"},{"key":"2026020210063514200_R19","first-page":"3484","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210063514200_R20","first-page":"174","volume-title":"Clin. Exp. Immunol.","year":"1993"},{"key":"2026020210063514200_R21","first-page":"459","volume-title":"Lancet","year":"1999"},{"key":"2026020210063514200_R22","first-page":"1029","volume-title":"N. Engl. J. Med.","year":"1997"},{"key":"2026020210063514200_R23","first-page":"521","volume-title":"Lancet","year":"1997"},{"key":"2026020210063514200_R24","first-page":"251","volume-title":"Cytokine","year":"1995"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/10\/5089\/62568220\/5089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/10\/5089\/62568220\/5089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:08:11Z","timestamp":1770044891000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/170\/10\/5089\/8028206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":24,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2003,5,15]]},"published-print":{"date-parts":[[2003,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.170.10.5089","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,5]]},"published":{"date-parts":[[2003,5]]}}}