{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:25:38Z","timestamp":1790911538153,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>LFA-1 (CD11a\/CD18) plays a crucial role in various inflammatory responses. In this study, we show that LFA-1\u2212\/\u2212 mice are far more resistant to Listeria monocytogenes infection than LFA-1+\/\u2212 mice. Consistent with this, we found the following: 1) the numbers of granulocytes infiltrating the liver were markedly higher in LFA-1\u2212\/\u2212 mice than in LFA-1+\/\u2212 mice, 2) increased antilisterial resistance in LFA-1\u2212\/\u2212 mice was abrogated by depletion of granulocytes, and 3) the numbers of granulocytes in peripheral blood, and the serum levels of both G-CSF and IL-17 were higher in LFA-1\u2212\/\u2212 mice than in LFA-1+\/\u2212 mice. Neither spontaneous apoptosis nor survival of granulocytes from LFA-1\u2212\/\u2212 mice were affected by physiological concentrations of G-CSF. Our data suggest regulatory effects of LFA-1 on G-CSF and IL-17 secretion, and as a corollary on neutrophilia. Consequently, we conclude that increased resistance of LFA-1\u2212\/\u2212 mice to listeriosis is due to neutrophilia facilitating liver infiltration by granulocytes promptly after L. monocytogenes infection, although it is LFA-1 independent.<\/jats:p>","DOI":"10.4049\/jimmunol.170.10.5228","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:31:23Z","timestamp":1398022283000},"page":"5228-5234","source":"Crossref","is-referenced-by-count":45,"title":["Neutrophilia in LFA-1-Deficient Mice Confers Resistance to Listeriosis: Possible Contribution of Granulocyte-Colony-Stimulating Factor and IL-17"],"prefix":"10.1093","volume":"170","author":[{"given":"Mamiko","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Immunology, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Emoto","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Emoto","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Central Core Facility, Microscopy, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Seiler","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Aichele","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H E","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max-Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,5,15]]},"reference":[{"key":"2026020210124994000_R1","first-page":"827","volume-title":"Annu. 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