{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:16:53Z","timestamp":1780553813062,"version":"3.54.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The migration of dendritic cells (DCs) from the epithelia to the lymphoid organs represents a tightly regulated multistep event involved in the induction of the immune response. In this process fatty acid derivatives positively and negatively regulate DC emigration. In the present study we investigated whether activation of peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors activated by naturally occurring derivatives of arachidonic acid, could control DC migration from the peripheral sites of Ag capture to the draining lymph nodes (DLNs). First, we show that murine epidermal Langerhans cells (LCs) express PPAR\u03b3, but not PPAR\u03b1, mRNA, and protein. Using an experimental murine model of LC migration induced by TNF-\u03b1, we show that the highly potent PPAR\u03b3 agonist rosiglitazone specifically impairs the departure of LCs from the epidermis. In a model of contact allergen-induced LC migration, PPAR\u03b3 activation not only impedes LC emigration, and their subsequent accumulation as DCs in the DLNs, but also dramatically prevents the contact hypersensitivity responses after challenge. Finally, after intratracheal sensitization with an FITC-conjugated Ag, PPAR\u03b3 activation inhibits the migration of DCs from the airway mucosa to the thoracic LNs and also profoundly reduces the priming of Ag-specific T lymphocytes in the DLNs. Our results suggest a novel regulatory pathway via PPAR\u03b3 for DC migration from epithelia that could contribute to the initiation of immune responses.<\/jats:p>","DOI":"10.4049\/jimmunol.170.10.5295","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:31:23Z","timestamp":1398022283000},"page":"5295-5301","source":"Crossref","is-referenced-by-count":70,"title":["Peroxisome Proliferator-Activated Receptor \u03b3 Inhibits the Migration of Dendritic Cells: Consequences for the Immune Response"],"prefix":"10.1093","volume":"170","author":[{"given":"Ve\u0301ronique","family":"Angeli","sequence":"first","affiliation":[{"name":"Unite\u0301 547, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Hammad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Erasmus Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Staels","sequence":"additional","affiliation":[{"name":"Unite\u0301 545, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Capron","sequence":"additional","affiliation":[{"name":"Unite\u0301 547, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Erasmus Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Trottein","sequence":"additional","affiliation":[{"name":"Unite\u0301 547, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Institut Pasteur de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,5,15]]},"reference":[{"key":"2026020210123574200_R1","first-page":"245","volume-title":"Nature","year":"1998"},{"key":"2026020210123574200_R2","first-page":"25","volume-title":"Immunol. 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