{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:16:58Z","timestamp":1790727418801,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The role of IFN-\u03b3 in the pathogenesis of autoimmune disease is controversial, being described as immunostimulatory in some studies and immunosuppressive in others. To determine the contribution of local expression of IFN-\u03b3, we derived NOD.H-2h4 transgenic mice overexpressing IFN-\u03b3 in a thyroid-restricted manner. Transgenic mice, which had serum IFN-\u03b3 levels similar to wild-type littermates, showed up-regulation of MHC class II on thyrocytes, but did not develop spontaneous thyroiditis. Upon immunization with murine thyroglobulin, transgenic mice developed milder disease and reduced IgG1 responses compared with wild type. The milder disease was associated with decreased frequency of activated CD44+ lymphocytes in the cervical lymph nodes. This suppressive effect was confirmed by showing that blockade of systemic IFN-\u03b3 with mAb enhanced disease and increased IgG1 responses. The study supports a disease-limiting role of IFN-\u03b3 in autoimmune thyroiditis. Furthermore, it provides the first evidence that local IFN-\u03b3 activity in the thyroid is sufficient for disease suppression.<\/jats:p>","DOI":"10.4049\/jimmunol.170.11.5523","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:09:10Z","timestamp":1398024550000},"page":"5523-5529","source":"Crossref","is-referenced-by-count":27,"title":["Thyroid-Specific Expression of IFN-\u03b3 Limits Experimental Autoimmune Thyroiditis by Suppressing Lymphocyte Activation in Cervical Lymph Nodes"],"prefix":"10.1093","volume":"170","author":[{"given":"Jobert G","family":"Barin","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Afanasyeva","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Johns Hopkins University , Baltimore, MD 21205"},{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica V","family":"Talor","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel R","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Johns Hopkins University , Baltimore, MD 21205"},{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Lynne","family":"Burek","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Johns Hopkins University , Baltimore, MD 21205"},{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Caturegli","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"2026020210043650700_R1","first-page":"34","volume-title":"Immunol. Today","year":"1995"},{"key":"2026020210043650700_R2","first-page":"55","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020210043650700_R3","first-page":"37","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020210043650700_R4","first-page":"739","volume-title":"J. Clin. Invest.","year":"1991"},{"key":"2026020210043650700_R5","first-page":"13844","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1997"},{"key":"2026020210043650700_R6","first-page":"3999","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020210043650700_R7","first-page":"1506","volume-title":"J. Immunol.","year":"1988"},{"key":"2026020210043650700_R8","first-page":"105","volume-title":"J. Neuroimmunol.","year":"1992"},{"key":"2026020210043650700_R9","first-page":"1821","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210043650700_R10","first-page":"890","volume-title":"J. Immunol.","year":"1994"},{"key":"2026020210043650700_R11","first-page":"219","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020210043650700_R12","first-page":"3503","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210043650700_R13","first-page":"3145","volume-title":"Circulation","year":"2001"},{"key":"2026020210043650700_R14","first-page":"5464","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020210043650700_R15","first-page":"223","volume-title":"Clin. Immunol. Immunopathol.","year":"1997"},{"key":"2026020210043650700_R16","first-page":"73","volume-title":"Immunol. Lett.","year":"2000"},{"key":"2026020210043650700_R17","first-page":"64","volume-title":"Clin. Exp. Immunol.","year":"1991"},{"key":"2026020210043650700_R18","first-page":"139","volume-title":"Exp. Clin. Endocrinol.","year":"1991"},{"key":"2026020210043650700_R19","first-page":"3290","volume-title":"Eur. J. Immunol.","year":"1997"},{"key":"2026020210043650700_R20","first-page":"242","volume-title":"J. Immunol.","year":"1968"},{"key":"2026020210043650700_R21","first-page":"412","volume-title":"Proc. Soc. Exp. Biol. Med.","year":"1968"},{"key":"2026020210043650700_R22","first-page":"1137","volume-title":"Science","year":"1971"},{"key":"2026020210043650700_R23","first-page":"427","volume-title":"Immunogenetics","year":"1982"},{"key":"2026020210043650700_R24","first-page":"41","volume-title":"Acta Endocrinol.","year":"1990"},{"key":"2026020210043650700_R25","first-page":"275","volume-title":"Eur. J. Immunol.","year":"1993"},{"key":"2026020210043650700_R26","first-page":"2219","volume-title":"J. Immunol.","year":"1992"},{"key":"2026020210043650700_R27","first-page":"5105","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020210043650700_R28","first-page":"201","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026020210043650700_R29","first-page":"501","volume-title":"Int. Rev. Immunol.","year":"2000"},{"key":"2026020210043650700_R30","first-page":"1719","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020210043650700_R31","first-page":"793","volume-title":"J. Exp. Med.","year":"1993"},{"key":"2026020210043650700_R32","first-page":"287","volume-title":"Clin. Immunol. Immunopathol.","year":"1996"},{"key":"2026020210043650700_R33","first-page":"755","volume-title":"Thyroid","year":"2002"},{"key":"2026020210043650700_R34","first-page":"511","volume-title":"Biochim. Biophys. Acta","year":"1999"},{"key":"2026020210043650700_R35","first-page":"46","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020210043650700_R36","first-page":"2348","volume-title":"J. Immunol.","year":"1986"},{"key":"2026020210043650700_R37","first-page":"2511","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020210043650700_R38","first-page":"129","volume-title":"J. Autoimmun.","year":"2002"},{"key":"2026020210043650700_R39","first-page":"363","volume-title":"Curr. Opin. Immunol.","year":"2001"},{"key":"2026020210043650700_R40","first-page":"597","volume-title":"Cell","year":"1999"},{"key":"2026020210043650700_R41","first-page":"609","volume-title":"Cell","year":"1999"},{"key":"2026020210043650700_R42","first-page":"367","volume-title":"Trends Immunol.","year":"2001"},{"key":"2026020210043650700_R43","first-page":"33","volume-title":"Nat. Rev. Mol. Cell. Biol.","year":"2003"},{"key":"2026020210043650700_R44","first-page":"3120","volume-title":"J. Immunol.","year":"1987"},{"key":"2026020210043650700_R45","first-page":"331","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020210043650700_R46","first-page":"733","volume-title":"Immunity","year":"1998"},{"key":"2026020210043650700_R47","first-page":"1115","volume-title":"Lancet","year":"1983"},{"key":"2026020210043650700_R48","first-page":"243","volume-title":"Annu. Rev. Immunol.","year":"1991"},{"key":"2026020210043650700_R49","first-page":"141","volume-title":"Immunity","year":"1999"},{"key":"2026020210043650700_R50","first-page":"319","volume-title":"Science","year":"2001"},{"key":"2026020210043650700_R51","first-page":"63","volume-title":"Immunology","year":"1976"},{"key":"2026020210043650700_R52","first-page":"345","volume-title":"Clin. Immunol. Immunopathol.","year":"1986"},{"key":"2026020210043650700_R53","first-page":"140","volume-title":"Cell Immunol.","year":"1990"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/11\/5523\/62567595\/5523.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/170\/11\/5523\/62567595\/5523.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:05:24Z","timestamp":1770044724000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/170\/11\/5523\/8028073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,1]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2003,6,1]]},"published-print":{"date-parts":[[2003,6,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.170.11.5523","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,6]]},"published":{"date-parts":[[2003,6,1]]}}}