{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:45:19Z","timestamp":1771533919311,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tissue eosinophilia probably plays important roles in the pathophysiology of bronchial asthma and allergic disorders; however, this concept was challenged recently by controversial results in mouse models of bronchial asthma treated with anti-IL-5 Ab and the failure of anti-IL-5 therapy in humans. We have now used a unique model, IL-5 transgenic (TG) mice, to address a fundamental question: is airway eosinophilia beneficial or detrimental in the allergic response? After sensitization and challenge with OVA, IL-5 TG mice showed a marked airway eosinophilia. Surprisingly, these IL-5 TG mice showed lower airway reactivity to methacholine. Immunohistochemical analysis of the lungs revealed a marked peribronchial infiltration of eosinophils, but no eosinophil degranulation. In vitro, mouse eosinophils from peritoneal lavage fluids did not produce superoxide anion, but did produce an anti-inflammatory and fibrotic cytokine, TGF-\u03b21. Indeed, the TGF-\u03b21 levels in bronchoalveolar lavage fluid specimens from IL-5 TG mice directly correlated with airway eosinophilia (r = 0.755). Furthermore, anti-IL-5 treatment of IL-5 TG mice decreased both airway eosinophilia and TGF-\u03b21 levels in bronchoalveolar lavage fluids and increased airway reactivity. Thus, in mice, marked eosinophilia prevents the development of airway hyper-reactivity during an allergic response. Overall, the roles of eosinophils in asthma and in animal models need to be addressed carefully for their potentially detrimental and beneficial effects.<\/jats:p>","DOI":"10.4049\/jimmunol.170.11.5756","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:09:10Z","timestamp":1398024550000},"page":"5756-5763","source":"Crossref","is-referenced-by-count":48,"title":["Marked Airway Eosinophilia Prevents Development of Airway Hyper-responsiveness During an Allergic Response in IL-5 Transgenic Mice"],"prefix":"10.1093","volume":"170","author":[{"given":"Takao","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Iijima","sequence":"additional","affiliation":[{"name":"Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Kita","sequence":"additional","affiliation":[{"name":"Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"2026020210132227400_R1","first-page":"687","volume-title":"Arch. 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