{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:50:09Z","timestamp":1787946609902,"version":"build-2784847793"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Common variable immunodeficiency (CVID) is a heterogeneous group of B cell deficiency syndromes. T cell abnormalities are present in a high proportion of patients with CVID, suggesting impaired T cell-mediated stimulation of B cells. Based on the importance of IL-10 for B cell function and the involvement of the cAMP\/protein kinase A type I (PKAI) system in IL-10 synthesis, we examined IL-10 secretion in T cells from CVID patients and controls, particularly focusing on possible modulatory effects of the cAMP\/PKAI system. Our main findings were: 1) anti-CD3 and anti-CD3\/anti-CD28 activated T cells from CVID patients secreted less IL-10 than healthy controls. This defect was not related to varying proportions of T cell subsets (e.g., CD4+\/CD8+, CD45RA+\/RO+, or CD28\u2212 T cells); 2) PKAI activation through the cAMP agonist 8-CPT-cAMP markedly inhibited IL-10 secretion from T cells through CD3 and CD28 activation in both patients and controls, but the sensitivity for cAMP-dependent inhibition was increased in CVID; 3) selective PKAI inhibition by Rp-8-Br-cAMPS markedly increased IL-10 secretion in anti-CD3 and anti-CD3\/anti-CD28-stimulated T cells in both patients and controls. Even at the lowest concentrations of Rp-8-Br-cAMPS, IL-10 secretion in CVID patients reached levels comparable to those in controls. Our findings suggest impaired secretion of IL-10 by T cells from CVID patients, suggesting a possible link between T cell deficiency and impaired B cell function in CVID. The involvement of the cAMP\/PKAI system in this defect suggests a novel target for therapeutic immunomodulation in CVID.<\/jats:p>","DOI":"10.4049\/jimmunol.170.11.5772","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:09:10Z","timestamp":1398024550000},"page":"5772-5777","source":"Crossref","is-referenced-by-count":57,"title":["Impaired Secretion of IL-10 by T Cells from Patients with Common Variable Immunodeficiency\u2013Involvement of Protein Kinase A Type I"],"prefix":"10.1093","volume":"170","author":[{"given":"Are Martin","family":"Holm","sequence":"first","affiliation":[{"name":"Research Institute for Internal Medicine, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pa\u030al","family":"Aukrust","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine, University of Oslo , Oslo ,","place":["Norway"]},{"name":"Section for Clinical Immunology and Infectious Diseases, Medical Department, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar Martin","family":"Aandahl","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Mu\u0308ller","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine, University of Oslo , Oslo ,","place":["Norway"]},{"name":"Department of Microbiology, National Hospital, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjetil","family":"Taske\u0301n","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig S","family":"Fr\u00f8land","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine, University of Oslo , Oslo ,","place":["Norway"]},{"name":"Section for Clinical Immunology and Infectious Diseases, Medical Department, University of Oslo , Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"2026020210133093000_R1","first-page":"1","volume-title":"Clin. 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